Integrated Program in Neuroscience Home Page | Integrated Program in Neuroscience

Almazan, Guillermina

works with J. AntellEmail

Patents

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Multiple Sclerosis

Myelination
Oligodendrocytes

Antel, Jack

group leader, NeuroImm. Res. GroupEmail Website Publications

Multiple Sclerosis

Immune-neural interaction
Inflammation

Archambault, Philippe

Email Website Publications

Basic Neuroscience
Physical Disabilities

Motor learning
Rehabilitation
Robotics
Virtual reality
Wheelchair

Armony, Jorge

Email Website Publications

Cognitive Neuroscience

Attention
Behaviour
Fear
Memory

Armstrong, Gary

Email Publications

ALS
Basic Neuroscience
Genomics

Animal models
Neural circuits
Neurophysiology
CRISPR Genome Editing

Arnold, Douglas

member, NeuroImaging & Neuroinform Res.Email Publications

Alzheimer's Disease
Multiple Sclerosis

Neuroimaging
Treatment

Auclair-Ouellet, Noémie

Email Website Publications

Cognitive Neuroscience

Aging
Communication
Dementia
Language
Neuroimaging

Avoli, Massimo

member, Epilepsy Res. GroupEmail Publications

Epilepsy

Animal models
Electrophysiology
Neuronal circuits
Treatment

Bagot, Rosemary

Email Publications

Depression

Animal models
Behaviour
Electrophysiology
Genetics

Baillet, Sylvain

contributed image analysis techniques for the early prediction of infarct growth in stroke, with diffusion-weighted MRI and innovative image analysis methods. These latter have been successfully transferred to the biomedical imaging industry. Group LeaderEmail Website Publications

Cognitive Neuroscience

Clinical investigation
Computational models
Neuroimaging
Treatment

Sylvain Baillet is a physicist with research interests in methodological developments for functional and structural brain imaging and their application to clinical and cognitive Neuroscience. Although his primary expertise is with MEG (magnetoencephalography) imaging, he also contributed new techniques for MRI image segmentation and inter-subject registration. He has also initiated new image analysis techniques for the early prediction of infarct growth in stroke patients, using diffusion-weighted MR sequences. His current research projects with MEG include real-time therapeutic imaging, the evaluation of resting-state brain activity and connectivity in the healthy and diseased brain, and the development of original data mining and visualization techniques for time-resolved brain image series. He has also great interest in disseminating his research through academic software: he is a founding developer of the Brainstorm open-source software project (http://neuroimage.usc.edu/brainstorm) for MEG and EEG imaging with MRI integration.

Baker, Curtis

McGill Vision ResearchEmail Website Publications

Cognitive Neuroscience
Vision

Animal models
Computational models
Neuroimaging
Neurophysiology

Baum, Shari

Email Website Publications

Cognitive Neuroscience

Behaviour
Language
Neuroimaging
Speech

Beaulieu, Serge

Medical Chief, Mood, Anxiety and Impulsivity Disorders Program, Medical Chief, Bipolar Disorders Program, Medical Director, Clinical Activities, Knowledge Transfer and TeachingEmail Website

Bipolar Disorder

Neuroendocrinology
Psychopharmacology

Areas of Expertise

Bipolar disorder, psychopharmacology, stress, depression, neuroendocrinology

Profile

After completing a post-doctoral research fellowship training at the Biological Psychiatry Branch of the National Institutes of Health (Bethesda, MD, USA) with Robert M. Post, MD, Serge Beaulieu, MD, PhD, FRCPC, joined the Douglas Institute in 1997 and assumed the post of director of the Mood Disorders Programs. At McGill University, he is an associate professor in the Department of Psychiatry and an associate member of the Department of Neurology and Neurosurgery.

A psychiatrist and researcher-clinician, Serge Beaulieu is interested primarily in bipolar disorders (manic depressive illness) and major depression. He studies neurobiological responses to antidepressant and mood stabilizer treatment and potential new treatments for these disorders.

Serge Beaulieu has received diverse peer-reviewed research funding from the National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD, USA), the Stanley Foundation (USA), the Fonds de la recherche en santé du Québec (FRSQ), the Canadian Fund for Innovation (CFI) and the Canadian Institutes of Health Research (CIHR).

He is a member of the board of governors of the Canadian Network on Mood and Anxiety Treatment (CANMAT), a member of the Board of Councilors of the International Society of Bipolar Disorders (ISBD) and one of the investigators and founding members of the Canadian Bipolar Consortium.

Awards and Distinctions
Serge Beaulieu is the recipient of the 2004 Douglas Utting Prize, awarded annually to one individual in Canada who has contributed significantly to promote research and treatment on depression and awareness of depression.

Bedell, Barry

member, NeuroImaging & Neuroinform Res.Email Website

Alzheimer's Disease
Multiple Sclerosis
Oncology

Animal models
Neuroimaging
Neuropathology
Brain tumours

The Neuro Team
Barry Bedell, M.D., Ph.D

Barry Bedell
Dr. Barry Bedell joined the faculty at the Montreal Neurological Institute and Hospital in July 2006 as an Assistant Professor in the Department of Neurology and Neurosurgery at McGill University. He is the first recruit to accept a position as part of the Montreal Consortium for Brain Imaging Research (MCBIR) initiative, which is a partnership between the MNI, McGill, the Douglas Hospital Research Centre and the Lady Davis Institute of the Jewish General Hospital.

A native of New Jersey, Dr. Bedell holds a B.S. (Chemistry) from Lehigh University (1992) and a Ph.D. in Medical Physics (1996) from the University of Texas Health Science Center at Houston. He obtained his M.D.C.M. from McGill University in 2001. While pursing his medical degree and completing his residency in pathology, Dr. Bedell conducted research with Dr. Alan Evans and colleagues in the McConnell Brain Imaging Centre.

Dr. Bedell will lead the effort to develop the animal imaging research program which will be housed in the new addition to the BIC in The Neuro's North Wing. His current research program is the development of an Integrated Technology Platform (ITP), which integrates MRI/PET imaging, histopathological, and molecular studies in animal models of Alzheimer's disease, multiple sclerosis (MS), and brain tumours. As part of this multi-disciplinary research, Dr. Bedell has recently established a state-of-the-art experimental neuropathology facility which focuses on high-throughput production of quantitative data from tissue sections and seamless integrates with the animal imaging activities.

Berlim, Marcelo

Director, Neuromodulation Research Clinic, Psychiatrist, Depressive Disorders ProgramEmail Website

Depression
Suicide

Neuroimaging
Neuromodulation
Suicide
Treatment

Bernard, Daniel

Email Website Publications

Basic Neuroscience

Hormones
In vitro assay
In vivo assay
Signaling pathways

Bernard, Geneviève

Email Publications

Neurodegeneration

Genetics
Leukodystrophy
Neuroimaging
Pathophysiology
Phenotyping

Leukodystrophies are a group of over 20 genetically-determined disorders characterized by abnormal white matter on brain imaging. Typically, they are neurodegenerative diseases starting in previously healthy children, leading to progressive disabilities and death over months to years. They are classified into two categories, according to whether the primary problem is maintaining myelin homeostasis (non-hypomyelinating) or myelin deposition during development (hypomyelinating). I have built a comprehensive research program aimed at characterizing leukodystrophies clinically, radiologically, genetically and pathophysiologically. My research program is expanding to include perspectives from the study of epidemiology, natural history, and quality-of-life impacts, with the ultimate objective of improving care for children who face the serious challenges associated with this disease group. My research program focuses on hypomyelinating leukodystrophies, and more specifically on 4H or POLR3-related leukodystrophy. 4H is a hypomyelinating leukodystrophy characterized by neurological (i.e. cerebellar and pyramidal features, cognitive regression) and non-neurological (i.e. myopia, dental and endocrine abnormalities) characteristics. It is caused by recessive mutations in POLR3A, POLR3B and POLR1C, encoding subunits of RNA-polymerase III, which is the enzyme responsible for the transcription of small non-coding RNA important for primordial cellular processes. Using 4H leukodystrophy as the primary disease of interest, my research translational program has the following objectives: (1) Clinical and radiological characterization of known and novel disorders, (2) Identification and validation of novel causal genes, (3) Understanding the impacts of the disease on patients and family members over time, and the factors involved in alleviating or worsening these, (4) Understand the cellular mechanisms involved in hypomyelination, and more specifically, the contribution of transcription and translation on hypomyelination (5) Using an in vitro model of hypomyelination, intervene to improve myelination.

The overall aim of this program is to understand the clinical, radiological, genetic, molecular and pathophysiological bases of hypomyelinating leukodystrophies to develop innovative treatments and rapidly translate them into clinical practice for these devastating neurodevelopmental and neurodegenerative diseases.

Bernasconi, Andrea

member, Epilepsy Res. GroupEmail Website Publications

Epilepsy

MRI
Neuroimaging

Bernhardt, Boris

Email Website Publications

Autism
Epilepsy

Behaviour
Biomarkers
Diagnostics
Neuroimaging

Bertone, Armando

director of the Perceptual Neuroscience Laboratory for Autism and Development (PNLab)Email Website Publications

Autism
Cognitive Neuroscience

Behaviour
Development
Diagnostics
Neuropsychology
Perception

Blain-Moraes, Stefanie

Email Website Publications

Cognitive Neuroscience

Biomusic
Diagnostics
Disability
Interaction
Neurophysiology
Non-communicative person
Quality of life

Blanchette, Mathieu

Email Website Publications

Basic Neuroscience

Algorithm
Computational models
Epigenetics
Genomics

We develop cutting-edge computational approaches to key questions in genomics and evolution. We design algorithmic, machine learning, and statistical approaches to solve real-world questions from biology, and work in tight collaboration with biologists, biochemists, and geneticists to put our tools to use to make biological discoveries. We are particularly interested in: (i) How do genomes evolve, and what does that tell us about their functions? (ii) How is gene expression regulated, and what role does 3D chromosome organization play? Of particular interest in the context of our work are normal and cancer brain cells. We are studying how chromatin conformation evolves as cells differentiate from embryonic stem cells to neural progenitor cells to neuron, and how expression changes accompany chromatin structure changes. In brain cancer, we are working with Nada Jabado’s lab to map the 3D organization of chromatin in various types of paediatric brain tumours, identify markers of different types of cancer, and link these changes to other genetic and epigenetic changes, with the goal of identifying putative therapeutical targets.

Bohbot, Véronique

Email Website Publications

ADHD
Alzheimer's Disease
Cognitive Neuroscience
Depression
Diabetes
Epilepsy
MCI
Parkinson's Disease
Schizophrenia

Memory
Neuroimaging
Neuropsychology
Plasticity
Virtual navigation

Boivin, Diane

Founder/Director, Centre for Study and Treatment of Circadian Rhythms,Email Website Publications

Patents

Sleep

Circadian rhythms
Phototherapy
Treatment

Boksa, Patricia

Email Publications

Schizophrenia

Animal models
Brain development
Cytokines
Dopamine
Inflammation
Newborn
Oxytocin

Boudrias, Marie-Hélène

Email Website Publications

Aging
Stroke

Biomarkers
Electrophysiology
Motor function
Neuroimaging

Bourque, Charles

Centre for Research in NeuroscienceEmail Website Publications

Basic Neuroscience

Immune-neural interaction
Ion channels
Osmoreceptors

Bowie, Derek

Director of the FRQS-funded research group, GEPROMEmail Website Publications

ADHD
Ataxia
Autism
Basic Neuroscience
Down syndrome
Epilepsy
Hyperactivity
Mental Disorder
Stroke
Vision

Electrophysiology
Gaba-a
Glutamatergic systems
Ion channels
Mental retardation
Neurodevelopment
Receptors
Structural biology
Synapse plasticity
Therapeutics targets
GABA-A

Brais, Bernard

group leader, Rare Neurol. Dis. co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital, and Director of the CHUM ataxia centreEmail Website Publications

Patents

License

Ataxia
Leukodystrophies
Leukoencephalopathies
Musucular Dystrophies
Myopathies
Sensory and Autonomic Neuropathies

Cerebellar pathology
Genetics
Muscle pathology
Population genetics
Transgenic mice models

Brandon, Mark

Email Website Publications

Cognitive Neuroscience

Electrophysiology
Optogenetics

Braverman, Nancy

Email Publications

Britt, Jonathan

Email Website Publications

Addiction
Cognitive Neuroscience
OCD
Tourette's Syndrome

Animal models
Drug abuse
Electrophysiology
Optogenetics
Behaviour
Learning
Neural circuits
Neuronal circuits

Brunet, Alain

Director, Psychosocial Research DivisionEmail Website Publications

PTSD

Assessment
Risk factors
Treatment

Bzdok, Danilo

Email Website Publications

Cayouette, Michel

director of the Cellular Neurobiology LaboratoryEmail Website Publications

Alzheimer's Disease
Neurodegeneration
Parkinson's Disease
Vision

Genetics
Retina
Stem cells

Cermakian, Nicolas

Director, Laboratory of Molecular ChronobiologyEmail Website Publications

Basic Neuroscience
Infections
Sleep

Animal models
Immune-neural interaction
Circadian rhythms
Genetics
Immune response
Phototherapy

Cervero, Fernando

Faculty of Dentistry, Alan Edward Centre for Res. In PainEmail Website Publications

Pain

Analgesia
Animal models
Behaviour
Hormones
Interstitial cystitis
Ion channels
Nociception
Therapeutic targets
Visceral

Chacron, Maurice

Computational Systems Neuroscience LaboratoryEmail Website Publications

Basic Neuroscience

Animal models
Behaviour
Electrophysiology
Modeling
Sensory processing

Chakravarty, Mallar

leads the Computational Brain Anatomy (CoBrA) Laboratory at the Brain Imaging Centre.Email Website Publications

Basic Neuroscience

Brain anatomy
Computational models
Neuroimaging

Magnetic resonance imaging (MRI) is one of the tools of choice for the analysis of the brain in normally functioning and diseased states. Different MRI acquisition protocols provide excellent contrast and resolution and can be analyzed using automated techniques. The goal of Dr. Chakravarty’s work is to develop and use computational neuroanatomical techniques to understand how the structure of the brain is altered in psychiatric disorders. These techniques include the automated identification of structures and computational metrics that quantify their shape.  He is currently working on adding information from diffusion tensor imaging in order to describe inter-structural connectivity.  Many of these techniques can be used to elucidate phenotypes that can help describe brain risk for the major psychosis or pathological ageing.  To date, Dr. Chakravarty and the Computational Brain Anatomy (CoBrA) Laboratory have been using these techniques to better understand the alterations in brain anatomy that underly the major psychoses, ageing, brain development, and Alzheimer's disease.

Charron, Frederic

director of the Molecular Biology of Neural Development Laboratory at the Université de Montréal and affiliated with McGill University.Email Website Publications

Basic Neuroscience

Axon
Genetics
Hedgehog
Neural circuits
Neuroimaging
Neuronal circuits

Chen, Brian

Email Website Publications

Patents

License

Basic Neuroscience

Animal models
Dscam receptors
Genetics
Neural circuits
Neuroimaging
Neuronal circuits

Clarke, Paul

Email Website Publications

Behavioural neuroscience

Amphetamine
Animal behaviour
Animal models
Cocaine
Dopamine
Nicotine
Nicotinic cholinergic receptors
Noradrenaline
Opioids

Cloutier, Jean-Francois

Member, Neural circuits Res.Email Website Publications

Basic Neuroscience

Animal models
Axon
Regeneration
Therapeutics

Dr. Jean-François Cloutier’s research is aimed at understanding the molecular mechanisms that control axonal pathfinding during development of the nervous systems. The formation of accurate connections between the peripheral and central nervous systems is essential for the functioning of the various sensory systems that allow us to detect odors, sounds, tastes, pain, and temperature. While the basic anatomical principles of wiring in these systems are well understood, little is known about the mechanisms involved in establishing these wiring patterns.

Dr.Cloutier uses a combination of in vivo mouse genetic models and molecular biological approaches to identify cues involved in guiding axons of primary sensory neurons to their targets and to characterize intracellular signals that function downstream of these axon guidance cues. Gaining insight into the basic mode of action of guidance molecules will be important in the future development of therapies for neurological disorders and injuries requiring regeneration of specific axonal connections.

Coderre, Terence

director of pain research laboratories in the Anesthesia Research Unit and at the MUHC Research Institute, and a member of the McGill Centre for Research on Pain.Email Website Publications

Patents

Pain

Animal models
Behaviour
CRPS
Microscopy
Neurochemistry
Neuropharmacology
Plasticity

Collins, Louis

Joint Appointment in BioMedical Engineering -member, NeuroImaging & Neuroinform Res.Email Website Publications

Patents

License

Basic Neuroscience

Neuroimaging
Neuroinformatics
Treatment

Cook, Erik

Basic Neuroscience
Vision

Behaviour
Computational models
Electrophysiology
Visual perception

Cooper, Ellis

Email Website

Basic Neuroscience

Animal models
Electrophysiology
Neural circuits
Neuronal circuits
Synapse

Cuello, Claudio

Email Publications

License

Aging
Alzheimer's Disease

Animal models
Degeneration
Regeneration

Our laboratory focuses in degenerative and regenerative processes in the CNS with particular emphasis on aging and Alzheimer’s disease (AD) related studies. The group utilizes and develops transgenic animal models presenting features of the AD neuropathology. The research is of a multidisciplinary nature ranging from molecular approaches to whole animal experimentation and with a particular interest in cell and animal models of the Alzheimer’s disease and experimental therapeutics.
Professor Cuello has been trained at the Universities of Buenos Aires (UBA, Argentina), U. C. San Francisco (USA) and Cambridge (England). He held research and academic positions  in the Departments of Pharmacology at both Cambridge and Oxford. He is a past Chair of the McGill Department of Pharmacology and Therapeutics and presently holds the Charles E. Frosst Merck Chair within the same Department. He is also currently an Associate Member of the Departments of Anatomy and Cell Biology and Neurology and Neurosurgery at McGill University, adjunct Professor of the Scripps Institute (LaJolla) and Visiting Professor at Oxford University.

Dagher, Alain

neurologist specializing in movement disorders and functional brain imaging. Member, Neuroimaging & Neuroinform.Email Publications

Addiction
Eating Disorders
Parkinson's Disease
Stress

Basal ganglia
Dopamine
Neuroimaging
Neurotransmitters

Daniel, Sam

Pediatric Otolaryngologist and Director, Otolaryngology–Head and Neck Surgery Director, McGill Auditory Sciences LaboratoryEmail Website Publications

Hearing

Animal models
Computational models
Ototoxicity
Prevention
Therapeutics

David, Samuel

in Centre for Research in Neuroscience, MGHEmail Publications

Patents

License

Multiple Sclerosis
Spinal Cord Injury
Stroke

Animal models
Cell culture
Iron homeostasis in the CNS
Neuroinflammation

de Villers-Sidani, Etienne

member, neural Circuits Res.Email Publications

Cognitive Neuroscience
Hearing

Electrophysiology
Sensory-motor processing
Therapeutics

Debruille, J. Bruno

Email Website Publications

Cognitive neuroscience
Cognitive Neuroscience
Consciousness
Schizophrenia
Social

Event-related brain potentials
Experimental psychology
Psychopharmacology

Diatchenko, Luda

Email Website Publications

Pain

Animal models
Cellular models
Clinical trials
Genetics
Treatment

Diaz, Roberto

Email Website Publications

Oncology

Brain tumours
Cellular models
Genetics
Neurosurgery
Therapeutic targets

Doyon, Julien

Email Website

Aging
Basic Neuroscience
Cognitive Neuroscience
Parkinson's Disease
Sleep
Spinal Cord

Neuroimaging
Memory consolidation
Motor learning
Memory
Plasticity

Ducharme, Simon

Email Website Publications

Aging
Alzheimer's Disease
Dementia
Epilepsy
Neurodegeneration

Biomarkers
Neuroimaging
Clinical trials

Durcan, Thomas

Email Publications

Neurodegeneration
Parkinson's Disease

Animal models
Stem cells

Durham, Heather

Member, Rare Neurol. Dis.Email Publications

Basic Neuroscience

Animal models
Cell culture
Genetics
Imaging
Motor neurons
Treatment

El Mestikawy, Salah

Email Website

Basic Neuroscience

Animal models
Biomarkers
Diagnostics
Glutamergic systems
Neurotransmitters
Therapeutics

Elsabbagh, Mayada

manages the Knowledge Translation portfolio for NeuroDevNet, a Canadian national Network of Center’s of Excellence.MHC _ R&TEmail Website Publications

Autism

Behaviour
Childhood
EEG
Genetics

Ernst, Carl

Email Website Publications

Mental Disorder

Behaviour
Cellular models
Genetics
Screening assay
Stem cells

Evans, Alan

member, NeuroImaging & Neuroinform Res.Email Publications

Cognitive Neuroscience

Language
Memory
Neuroimaging
Neuroinformatics

Farivar, Reza

Patents

TBI
Vision

Diagnostics
Neuroimaging
Animal models

Fellows, Lesley

neurologist specializing in disorders of cognition Group leader, Cognitive NSEmail Publications

Cognitive Neuroscience

Frontal lobe
Neurochemistry

Ferland, Catherine

Email Publications

Pain

Children
Nociception
Surgery

Flores, Cecilia

Email Website Publications

Addiction
Depression
Mental Disorder
Neurodevelopmental disorders

Animal models
Susceptibility
Biomarkers

Fon, Edward

Director of the McGill Parkinson Program. Group leader Neurodeg. Disorder Res.Email Publications

Parkinson's Disease

Neurotransmitters
Therapeutics
Ubiquitin

Fournier, Alyson

member, neurodeg. Disorder Res.Email Website Publications

Basic Neuroscience

Cytoskeleton
Neurite outgrowth
Regeneration

Frauscher, Birgit

Email Website

Epilepsy
Sleep physiology

Biomarkers
Diagnostics
Scalp and intracranial EEG
Sleep
Source localization
Clinical neurophysiology

Gagnon, Isabelle

Email Website Publications

Concussion
TBI

Rehabilitation mobility
Balance
Concussion
Neuroimaging
Pediatrics
Rehabilitation
Visual perception

Gan-Or, Ziv

Email Publications

Parkinson's Disease
Sleep

Alpha synuclein
Behaviour
Genetics

Garzia, Livia

Email Publications

Genomics
Oncology

Oncology
Animal models
Brain tumours
Epigenetics
Genetics

Gauthier, Serge

Email Publications

Alzheimer's Disease

Clinical trials
Epidemiology

Gentil, Benoit

Email Website Publications

Giros, Bruno

Director, Schizophrenia and neurodevelopmental disorders research themeEmail Website Publications

Depression
PTSD
Schizophrenia

Animal models
Pre-clinical research
Signalization
Therapeutic
Translational
Neurotransmitters
Psychopharmacology

Gobbi, Gabriella

psychiatrist in the Mood Disorders Program at the MUHCEmail Website Publications

Depression
Mental Disorder
Pain
Sleep

Therapeutics
Psychopharmacology
Cannabis
Circadian rhythms

Gold, Ian

in Division of social and transcultural PsychiatryEmail Website

Mental Disorder

Cultural psychiatry
Delusion

Gotman, Jean

group leader, Epilepsy Res groupEmail Website Publications

Epilepsy

Eeg
Neuroimaging

Gratton, Alain

Email Website Publications

Addiction
Stress

Neurochemistry
Neurotransmitters
Psychopharmacology
Voltammetry
Neurodevelopment factors

The main focus of my research is on the brain circuitry that controls how we cope with stressors and its role in drug addiction. I am currently interested in the medial prefrontal cortex (PFC), a brain region that reaches its full development during late adolescence/early adulthood.  This brain region controls several complexe tasks such as decision-making and planning and has been implicated in the compulsive behavior of drug addicts.  In part because it matures slowly, the PFC is particularly vulnerable to insults which can cause it to develop abnormally and lead to maladaptive behavior. The PFC is also extremely sensitive to stressors and plays an important role in mounting the appropriate coping responses. The neurotransmitters, dopamine and glutamate, have been implicated in PFC-mediated coping responses to stressors and actions of addictive drugs.  For our studies we use voltammetry and microsensors to monitor, in behaving rats, minute changes in dopamine and glutamate transmission on a second-to-second basis.

Gruber, Reut

ADHD
Sleep

Childhood
Genetics
Infancy
Youth

Guitton, Daniel

Member, Neural CircuitsEmail Publications

Cognitive Neuroscience
Vision

Modeling
Motor function
Neural circuits
Neuronal circuits

Haegert, David

In Dept. of pathologyEmail Publications

Multiple Sclerosis

Biomarkers
Diagnostics
Disease progression
Genetics

Haghighi, Pejmun

Email Website

Basic Neuroscience

Animal models
Electrophysiology
Genetics
Neuroimaging
Synapse

Hamel, Edith

Member, Neural Circuits Res.Email Publications

Alzheimer's Disease
Neurovascular Coupling
Vascular Dementia

Neural circuits
Cerebrovascular disease

Hardt, Oliver

Harnad, Stevan

affiliated at McGill, Canada Research Chair in Cognitive Sciences Primary Appointment at UQAMEmail Website Publications

Cognitive Neuroscience

Computational models
Language
Learning

Hastings, Ken

member, Rare Neurol Dis.Email Publications

Ataxia
Basic Neuroscience

Genetics
Animal models
Muscle

Healy, Luke

Email Publications

Basic Neuroscience
Multiple Sclerosis
Neuroinflammation

Autoimmunity
Inflammation
Microglia
Immune-neural interaction
Drug Screening

My group is focused on understanding both the positive and negative impact of microglia-mediated inflammation in a range of neurological disorders, with a particular focus on multiple sclerosis. We examine the functional and molecular basis of acute and chronic microglia-mediated inflammation and try to develop ways to modulate this. Microglia are the immune cells of the CNS and are the first responders to any pathological change to the CNS. The type and extend of the microglial response actively drives pathology and yet without this response subsequent repair of the CNS cannot occur. We work exclusively with human microglia, both purified from surgically resected tissues and derived through the reprogramming of induced pluripotent stem cells (iPSCs) from patients with specific disease-associated mutations. We strongly believe that studying human microglia (which are considerably different to their murine counterparts) will lead to biological insights and ultimately therapeutic targets with greater translatable potential.

Hendricks, Adam

Primary appointment in BioengineeeringEmail Website Publications

Neurodegeneration

Animal models
Behaviour
Cell assay
Engineering
In vitro assay
Motor protein

Many essential cellular functions including cell division, motility, protein synthesis, and intracellular transport are driven by motor proteins, a specialized set of enzymes that convert chemical energy into mechanical work. Two motor proteins, kinesin and cytoplasmic dynein, are responsible for the long-range transport of mRNA, proteins, organelles, and signaling molecules along the microtubule cytoskeleton. Active transport by kinesin and dynein is critical for the maintenance of biosynthetic, signaling, and degradative pathways in the cell. Long and highly-polarized cells like neurons are particularly sensitive, and accordingly mutations in kinesin or dynein cause neurodegenerative disease in mouse models and humans. Further, defects in intracellular transport have been linked to many neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, and Huntington’s disease.

In the complex cellular environment, kinesin and dynein are regulated by interactions with the cytoskeleton, other motor proteins, and binding partners. These interactions allow motors to perform complicated functions such as cell division and the targeted trafficking of intracellular cargoes. The Hendricks lab is focused on understanding how motor proteins function collectively, and how interactions among motor proteins and with the complex cellular environment modulate their behavior. We employ in vitro experiments that incorporate aspects of the cellular environment, high-resolution tracking and manipulation in living cells, and mathematical modeling to understand motor protein dynamics in the cell. In particular, we aim to develop methods to extend the application of single molecule techniques such as optical trapping, FRET, and subpixel resolution tracking to examine motor function in living cells.

Hendricks, Michael

Email Website Publications

Basic Neuroscience

Animal models
Behaviour
Neural circuits
Neuroimaging
Neuronal circuits

Hepple, Russell

Email Website Publications

Aging

Mitochondria
Muscle
Plasticity
Prevention

Hess, Robert

Director, McGill Vision ResearchEmail Website Publications

License

Vision

Amblyopia
Motion
Neuroimaging
Space
Video game

Huot, Philippe

Email Publications

Parkinson's Disease

Animal models
Basal ganglia
Therapeutic targets
Therapeutics

Iturria Medina, Yasser

Email Website Publications

Basic Neuroscience

Computational models
Engineering
Mental disorders
Neuroinformatics
Therapeutic targets

Jahani-Asl, Arezu

Email Website Publications

Basic Neuroscience

Brain tumours
Neuronal imaging

Joober, Ridha

Email Publications

ADHD
Schizophrenia

Animal models
Behaviour
Biomarkers
Diagnostics
Neuropsychology
Pharmacogenetics
Treatment

Juncker, David

Email Website Publications

License

Neurodegeneration

Biomarkers
Diagnostics
Nanotechnologies

Kaminska, Marta

Email Website Publications

Kania, Artur

Director, Neurobiology and Development research division , Director, Neural Circuit Development research unitEmail Website Publications

ALS
Basic Neuroscience
Neurodegeneration
Neurodevelopmental Disorders
Pain

Therapeutics
Axon
Motor function
Axon guidance
Behaviour
Chronic Pain
Ephrin-Eph Signalling
Genetics
Molecular Neuroscience
Netrin
Neural circuits
Neural development
Nociception
Spinal Cord
Chronic pain
Molecular neuroscience

Karama, Sherif

Email Publications

ADHD
Aging
Cognitive Neuroscience
Normal Brain Development

Neurodevelopment
Brain and Cognitive Changes
Development
Genetics
Neuroendocrinology

Karamchandani, Jason

Director of Experimental Neuropathology at the MNIEmail Publications

Bioinformatics
Oncology

Rare diseases
Animal models
Biomarkers
Diagnostics
Neuropathology

Kennedy, Tim

member, neurodeg. Disorder Res.Email Publications

Patents

License

Basic Neuroscience

Myelination
Neural development
Plasticity
Synapse

Khadra, Anmar

Email Website Publications

Basic Neuroscience

Computational models
Neuronal rhythms

Khoutorsky, Arkady

Email Website Publications

Basic Neuroscience

Autism
Mental disorders

Kieffer, Brigitte

Scientific director, Douglas InstituteEmail Website

Addiction
Autism
Mood Disorder
Pain

Opiate receptors
Psychiatry

Kingdom, Fred

Email Website Publications

Vision

Colour
Neuroimaging
Perception
Psychophysics
Space

Klein, Denise

member, Cognitive NS groupEmail Publications

Cognitive Neuroscience

Diagnostics
Language
Neuroimaging

Kobayashi, Eliane

member, Epilepsy Res. GroupEmail Website Publications

Epilepsy

Eeg
Genetics
Immunohistochemistry
Neuroimaging
Neurophysiology

Kokoeva, Maia

Email Publications

Eating Disorders

Animal models
Electrophysiology
Genetics
Neuroendocrinology
Plasticity

Koski, Lisa

Neurorehabilitation Research Centre, Director of the Transcranial Magnetic Stimulation laboratory at the RVH.Email Website Publications

Aging

Behaviour
Cognition
Diagnostics
Motor function
Neuroimaging
Rehabilitation
Treatment

Kostikov, Alexey

Email Website Publications

Basic Neuroscience
Radiochemistry

Biomarkers
Neuroimaging
Neuropeptide Y
Neurotrophin
PET tracer development
Protein radiolabeling

Krishnaswamy, Arjun

Email Website Publications

Basic Neuroscience
Cellular Neuroscience
Neurodevelopmental Disorders
Vision

Electrophysiology
Imaging
Neural circuits
Neural development
Optogenetics
Molecular Neuroscience
Retina

Lachapelle, Pierre

Director, Visual ElectrophysiologyEmail Publications

Vision

Animal models
Diagnostics
Macular degeneration
Retina
Symptoms
Therapeutics

Ladbon Bernasconi, Neda

member, NeuroImaging & Neuroinform Res.Email Website Publications

Epilepsy

Cognition
Computational models
Neuroimaging
Plasticity

Lamarche-Vane, Nathalie

Rosalind and Morris Goodman Cancer Centre (GCC) - Interim ChairEmail Publications

Basic Neuroscience
Oncology

Animal models
In vitro assay
Neuroimaging
Neuronal navigation

Lamontagne, Anouk

Email Publications

Stroke

Locomotion
Motor function
Rehabilitation

Lehmann, Alexandre

Email Website Publications

Behavioural Neuroscience
Cognitive Neuroscience
Hearing

Neuroimaging
Computational models
Plasticity
Sensory-motor processing

Leonard, Gabriel

coordinates the MNH neuropsychology outpatient service. Member Cognitive NS groupEmail Publications

Cognitive Neuroscience

Neuropsychology
Prenatal
Smoking
Test development

Lepage, Martin

Email Publications

Anxiety
Psychosis
Schizophrenia

Diagnostics
Memory
Neuroimaging
Neuropsychology
Treatment

Levin, Leonard

Chair of OphthalmologyEmail Website Publications

Clinical Trials
Neuroprotection
Vision

Axonal disease
Drug development
Glaucoma
Retinal ganglion cells
Optic neuropathies
Therapeutics

Levin, Mindy

Tier 1 Canada Research Chair in Arm Motor Recovery and Rehabilitation (2005-2012).Email Website Publications

Basic Neuroscience
Physical Disabilities
Stroke

Diagnostics
Neurological lesion
Rehabilitation
Sensorimotor function
Spasticity

Leyton, Marco

also in NeurologyEmail Publications

Addiction

Clinical investigation
Clinical research unit
Neuroimaging
Psychiatry

Lomber, Stephen

Ma, Weiya

Email Publications

Pain

Animal models
Behaviour
Inflammation
Receptors

Marcoux, Judith

MUHCEmail

Surgery

Martel, Marc O.

Email Website Publications

Maysinger, Dusica

Email Website Publications

Basic Neuroscience

Diagnostics
Drug delivery
Microglia
Nanoparticles
Signaling pathways

McBride, Heidi

member, Rare Neurol Dis.,Email Website Publications

Basic Neuroscience
Neurodegeneration
Parkinson's Disease

Immunity
Mitochondria
Therapeutics

McKinney, Anne

Email Website

Alzheimer's Disease
Ataxia
Autism
Basic Neuroscience
Epilepsy
Nanodelivery tools
Neurodevelopmental disorders

Animal models
Astrocyte
Microscopy
Neuroimaging
Neuroinflammation
Synapse
Therapeutics

Research Description:

Dr R Anne McKinney obtained her Ph.D, at the University of Ulster in 1992 after completing her BSc.(Hons)undergraduate degree in Biomedical Sciences at the University of Ulster, Northern Ireland. She then spent the next 5 years in the Department of Neurophysiology at the Brain Research Institute, University of Zurich as a postdoctoral fellow under the supervision of Profs S.M. Thompson and B.H Gähwiler. In 1998 she obtained her own group at the Brain Research Institute University of Zurich. Dr McKinney has recently joined the Department of Pharmacology and Therapeutics.
Dr. McKinneys principle research interest is the mechanisms involved in development and maintenance of excitatory synapses in the CNS, during physiological and pathological conditions, such as epilepsy and mental retardation. The synaptogenesis and maintenance of synaptic structures, key issues in neuroscience, are still poorly understood despite intensive research efforts. Her group’s studies are concentrated on the hippocampus a brain region thought to be involved in learning and memory. The McKinney lab is using a combination of techniques including, 4-dimensional confocal laser scanning microscopy, analysis of receptor subtype localization using serial electron microscopy, transgenic animals and advanced electrophysiological techniques to investigate the structure and function of dendritic spines and their synapses. These methods allows them assess the structural basis of synaptic function using multiple approaches.

McPherson, Peter

member, neurodeg. Disorder Res., also in Neuro& neurosurgeryEmail Website Publications

Patents

License

Neurodegeneration

Cellular models
Endocytosis
Genetics
Membrane trafficking

Meaney, Michael

Scientific Director at the Ludmer Centre for Neuroinformatics and Mental Health, Director, Program for the Study of Behaviour, Genes and Environment,Email Website Publications

Mental Health
Stress

Childhood abuse
Epigenetics
Genetics
Maternal care
Synapse

Mechawar, Naguib

Director, Mood, Anxiety and Impulsivity-Related ThemeEmail Website Publications

Depression
Suicide

Immune-neural interaction
Glial cells

Naguib Mechawar is Associate Professor and Graduate Program Director in the Department of Psychiatry at McGill University, and head of the Neuroanatomy of mood disorders and suicide laboratory at the Douglas Institute. In 2001, he obtained his PhD in Neuroscience at the Université de Montréal, where he studied the development and fine morphometric properties of central neuromodulatory innervations under the supervision of Laurent Descarries. Following postdoctoral fellowships in Jean-Pierre Changeux's laboratory at the Pasteur Institute (2001-2003) and in Rémi Quirion's lab at the Douglas Hospital (2004-2006), he joined the Mcgill Group for Suicide Studies in January 2007 as independent researcher and Assistant Professor of Psychiatry at McGill. At that time, he also became director of the Douglas-Bell Canada Brain Bank. Since 2009, he has also been the director of the Stress, Mood- and Impulsivity-Related Disorders research program at the Douglas Institute.

Dr. Mechawar’s research, which is funded by national and international granting agencies, is mainly focused on the implication of glial cells in depression and suicide. His laboratory studies well-characterized postmortem brain samples with a combination of fine neuroanatomical and molecular approaches. The main objectives of his research are to describe (1) the cellular and molecular features displayed by glial cells in different regions of the human brain; and (2) to determine how these features are altered in major depression and suicide. Current projects include the characterization of astrocytes in the human brain, an investigation of cerebral neuroinflammatory markers in depression, and the examination of white matter composition and organization in depressed suicides having suffered from early life adversity.

Mendola, Janine

Email Website Publications

Cognitive Neuroscience
Vision

Binocular vision
Depth and shape perception
Neuroimaging
Visual awareness/attention
Visual disorders
Amblyopia

Milnerwood, Austen

Email Website Website Publications

Basic Neuroscience
Parkinson's Disease

Animal models
Biomarkers
Cell culture
Electrophysiology
Genetics
Plasticity
Neural connectivity
Synuclein

Misic, Bratislav

McConnell Brain Imaging CentreEmail Website Publications

Basic Neuroscience

Behaviour
Neuroimaging
Statistics

Mitsis, Georgios

Associate memberEmail Website Publications

Basic Neuroscience

Neuroimaging

Mogil, Jeffrey

Canada Research Chair in the Genetics of Pain (Tier I), E. P. Taylor Chair in Pain StudiesEmail Website Publications

Pain

Animal models
Behaviour
Genetics

Mullen, Kathy T.

at the McGill Vision Research, Dept. Of Ophtalmology - MUHCEmail Website Publications

Vision

Amblyopia
Behaviour
Childhood
Colour
Neuroimaging

Multhaup, Gerhard

Email Website Publications

License

Alzheimer's Disease
Neurodegeneration

Amyloid
Biomarkers
Diagnostics
Prevention
Therapeutic targets
Cellular models

Munter, Lisa

Email Publications

Alzheimer's Disease
Basic Neuroscience

Cholesterol
Therapeutic targets
Regulated intramembrane proteolysis

Murai, Keith

Centre for Research in NeuroscienceEmail Website Publications

Basic Neuroscience
Mental Disorder

Immune-neural interaction
Ionic balance
Postsynaptic physiology
Synapse

Nader, Karim

Also part of Faculty of ScienceEmail Publications

Cognitive Neuroscience

Behaviour
Emotions
Fear
Memory
Therapeutic target

Nadig, Aparna

Email Website Publications

Autism
Cognitive Neuroscience
Neurodevelopmental Disorders

Language
Music
Social inclusion
Social communication
Behaviour

Professor Nadig and the PoP lab members study language, social communication and social cognition in the neurotypical population and in people on the autism spectrum. One recent theme of work has been to better understand the enormous variability in language development in autism. Studies in this theme have focused on mechanisms of language learning and impairment and the effects of bilingualism on children with autism.
A second theme of work examines individual differences in the dynamics of social interaction. Here we are developing fine-grained methods to measure dyadic coordination and applying them to study subtle differences that may impact conversation abilities. In intervention settings we are exploring whether coordination with a therapist may be related to treatment outcomes. 
A third theme focuses on developing and evaluating innovative interventions to facilitate social communication and promote the social inclusion of people ASD. Studies have included randomized controlled trials of music therapy for school-aged children with autism, and of a transition program for young adults that emphasizes self-determination.

Nalbantoglu, Josephine

member, NeuroImm. Res. GroupEmail Publications

Alzheimer's Disease
Oncology

Amyloid
Animal models
Genetics
Therapeutics

Narayanan, Sridar

Email Website Publications

Multiple Sclerosis
Parkinson's Disease

Biomarkers
Clinical trials
Disease progression
Neuroimaging

Nguyen, Tuong-Vi

Email Publications

Mental Health
Normal Brain Development

Reproductive health
Neuroendocrinology
Puberty

Ohyama, Tomoko

Email Website Publications

Basic Neuroscience

Neural circuits

Orlowski, John

Email Website Publications

Patents

Basic Neuroscience
Intellectual Disability
Neurodevelopmental disorders

Imaging
Brain development
Neural ph homeostasis
Protein trafficking

Oskoui, Maryam

Email Publications

Childhood disabilities
Neurodegeneration
Physical Disabilities

Cerebral palsy
Outcomes
Children
Epidemiology
Childhood

Ostry, David

engineer and neuroscientist. Motor Control lab.Email Website Publications

Cognitive Neuroscience

Learning
Motor function
Robotics
Sensory function
Speech

Overbury, Olga

Email Publications

Aging
Vision

Electrophysiology
Rehabilitation
Visual perception

Pack, Christopher

group leader, Neural Circuits Res.Email Website Publications

Vision

Animal models
Modeling
Neurophysiology

Palmer, Caroline

Canada Research Chair in cognitave Neuropsychology of Performance, Sequence Production Lab.Email Website Publications

Cognitive Neuroscience

Memory
Motor function
Music

Pantopoulos, Kostas

Email Website Publications

Aging
Neurodegeneration

Animal models
Glial Cells
HO-1
Iron

Paquette, Caroline

Email Website Publications

Aging
Behavioural Neuroscience
Parkinson's Disease
Stroke

Electrophysiology
Motor function
Neuroimaging
Rehabilitation
Posture

Paudel, Hemant

LDIEmail Publications

Alzheimer's Disease
Parkinson's Disease

Biomarkers
Tau
Alpha synuclein

Pell, Marc

Associate Dean and Director, SCSDEmail Website Publications

Cognitive Neuroscience
Parkinson's Disease
Stroke

Behaviour
Emotions
Language
Neuropsychology

Pelufo Silveira, Patricia

Email Publications

Basic Neuroscience
Behavioural neuroscience
Stress

Behaviour
Dopamine
Food intake

Peterson, Alan

Dept. Of Oncology - MUHCEmail Publications

Patents

Multiple Sclerosis

Axon
Cytoskeleton
Immune-neural interaction
Myelination

Petrecca, Kevin

neurosurgeon, group leader of Brain TumorEmail Website

Patents

Oncology

Brain tumours
Glial cells
Neurosurgery
Therapeutics

Petrides, Michael

member Cognitive NS groupEmail Publications

Cognitive Neuroscience

Memory

Peyrache, Adrien

Email Website Publications

Sleep

Animal models
Behaviour
Electrophysiology
Optogenetics

Plourde, Gilles

McConnell Brain Imaging CentreEmail

Anesthesia

Neuroimaging

Poirier, Judes

Director, Molecular Neurobiology Unit,Email Website Publications

Patents

Alzheimer's Disease

Genetics
Pharmacogenetics
Risk factor
Treatment

Poline, Jean-Baptiste

Email Publications

Postuma, Ron

co-directs the National Residents Course in movement disordersEmail

Parkinson's Disease

Non-motor symptoms
Prognosis
Treatment

Prager-Khoutorsky, Masha

Email Website Publications

Basic Neuroscience

Animal models
Behaviour
Electrophysiology

Ptito, Alain

Director of the Department of Psychology of the McGill University Health Centre. Member Cognitive NS gorupEmail Publications

Parkinson's Disease
Stroke
TBI

Diagnostics
Neuroimaging
Athletes

Rabin, Rachel

Email Website Publications

Addiction
Schizophrenia

Cannabis
Cognition
Neuroimaging

Racine, Eric

Director, Neuroethics Research Unit, IRCM Adjunct ProfessorEmail Website

Ethics

Health care system

Ragsdale, David

Email Website Publications

Patents

License

Cognitive Neuroscience

Decision making

Rajah, Natasha

Director, Brain Imaging Centre, Douglas InstituteEmail Website

Aging
Cognitive Neuroscience

Memory
Neuroimaging
Statistics

My research focuses on conducting behavioral and neuroimaging studies in the cognitive neuroscience of memory, aging and dementia prevention.More specifically, my lab uses structural and functional magnetic resonance imaging (MRI) methods and univariate and multivariate image analysis to investigate  how specific biological and demographic variables (i.e. biological sex,  genetics, family history of illness, bilingualism,  sex hormones) impact the integrity of the neural networks mediating episodic memory function in young, middle-aged and older adults. I also conduct parallel studies in adults at risk of developing Alzheimer’s Disease in order to determine if there are pathological changes in brain structure/function in at-risk individuals who are potentially at pre-clinical stages of AD onset.
The goal of my research is to understand:
•	How does the brain encode and retrieve episodic memories?
•	What regional changes in brain structure & function influence learning and memory across the adult lifespan?
•	How do these changes differ in adults at-risk vs. not at-risk of AD?
•	What compensatory mechanisms are available at midlife and older age to promote optimal memory function across the adult lifespan?

My research is currently funded by an CIHR Operating Grant (2013-2018).

Selected References

1.	Rajah, M. N., et al. "Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife." NeuroImage: Clinical (2017). 
2.	Ankudowich, E., Pasvanis, S., & Rajah, M. N. (2017). Changes in the correlation between spatial and temporal source memory performance and BOLD activity across the adult lifespan. Cortex.
3.	Kwon, D., Maillet, D., Pasvanis, S., Ankudowich, E., Grady, C. L., & Rajah, M. N. (2016). Context memory decline in middle aged adults is related to changes in prefrontal cortex function. Cerebral Cortex, 26(6), 2440-2460.
4.	Ankudowich, E., Pasvanis, S., & Rajah, M. N. (2016). Changes in the modulation of brain activity during context encoding vs. context retrieval across the adult lifespan. NeuroImage, 139, 103-113.
5.	Maillet, D., & Rajah, M. N. (2016). Assessing the neural correlates of task-unrelated thoughts during episodic encoding and their association with subsequent memory in young and older adults. Journal of cognitive neuroscience.
6.	Rajah, M. N., Maillet, D & Grady, C.L. (2015).  Book Chapter: Episodic Memory in Healthy Older Adults: The Role of Prefrontal and Parietal Cortices. The Wiley Handbook of Cognitive Neuroscience of   Memory, D. Addis, M. Berense & A. Duarte (Eds). Wiley Publishers, 347-361
7.	Maillet, D. & Rajah, M. N. (2014) Dissociable roles of default-mode regions during episodic encoding. Neuroimage, 89: p. 244-55.

Rao, Yong

Centre for Research in Neuroscience, MGHEmail Publications

Basic Neuroscience

Animal models
Behaviour
Genetics
Neural circuits
Neuronal circuits
Therapeutics

Reader, Andrew

member, NeuroImaging & Neuroinform Res.Email Publications

Basic Neuroscience

Neuroimaging
Neuroinformatics

Renaud, Johanne

Medical Chief of the Child Psychiatry ProgramEmail Website Publications

Bereavement
Depression
Suicide

Behaviour
Childhood
Health services
Psychiatry
Treatment
Youth

Ribeiro-da-Silva, Alfredo

Email Website Publications

Pain

Animal models
Arthritis
Neuropathy
Therapeutics

Richards, Blake

Ristic, Jelena

Lab for attention and social cognitionEmail Website Publications

Cognitive Neuroscience

Attention
Neuroimaging

Rochford, Joseph

Director of Academic Affairs, Research Centre, Douglas Institute , Director, Neurophenotyping Centre,Email Website Publications

Cognitive Neuroscience

Animal models
Behaviour
Genetics
Phenotyping services

Roig, Marc

Email Website Publications

Basic Neuroscience

Memory consolidation
Motor learning
Motor memory

Rosa Neto, Pedro

Director of Translational Neuroimaging LaboratoryEmail Publications

Alzheimer's Disease
Dementia
Neurodegeneration

Animal models
Biomarkers
Diagnostics
Neuroimaging

Rouleau, Guy

Director of the Réseau de Médecine Génétique Appliquée – Fonds de recherche du Québec - Santé. Member, Neurodeg. Disorder Res.Email Website Publications

Patents

License

ALS
Ataxia
Mental Disorder
Restless Legs Syndrome
Stroke

Genetics

Roy, Mathieu

Email Publications

Clinical epidemiology
Cognitive Neuroscience
Pain

Biomarkers of pain
Executive functions
Behaviour
Chronic pain
Neuroimaging
Psychology

Rudko, David

Email Website Publications

Basic Neuroscience
Multiple Sclerosis
Neurodegeneration
Physics

Computational models
Microstructure
Neuroimaging
Animal models
MRI

Research in our lab is focused on the the application of novel MRI methodology in conjunction with biophysical modeling to augment the current understanding of brain anatomy and physiology. In neurological disease, the interplay between sub-voxel, cellular-level components such as microglia and axons executes a critical role in determining disease onset and progression. To investigate these features, our lab utilizes both small animal (7 T) and human MRI/MRS (3 T, 7 T) in conjunction with optical microscopy and advanced image processing methods. In particular, we develop MRI physics acquisition and post-processing techniques for mapping myelin density, axonal packing and axonal geometry.  Equally relevant, our lab also focuses on the advancement of physics, signal processing and hardware methodology for ultra-high field (UHF, > 3T) MRI. We develop computational and hardware/enginnering methods for (a) RF field homogenization (static and dynamic B1+ shimming methods) and (b) B0 shimming (B0 field mapping, gradient Z-shimming and multi-coil shim arrays).

Sadikot, Abbas

member, neurodeg. Disorder Res.Email Publications

Epilepsy
Oncology

Neuroimaging
Neurosurgery
Therapeutics

Sakata, Jon

Member CRBLMEmail Website

Autism
Cognitive Neuroscience

Animal models
Behaviour
Communication

Santaguida, Carlo

Saragovi, Uri

Email Website Publications

Patents

License

Basic Neuroscience
Neuroprotection
Vision

Neurotrophin
Rational drug design
Retinal ganglion cells
Therapeutics
Retinal degeneration

Research in my laboratory focuses in understanding macromolecular structure function relationships, particularly in receptor-ligand interactions. We apply this knowledge to translational research and to experimental therapeutics. We have contributed towards the development of protein mimicry technology (reviewed in Nature Biotechnology, 10: 773; Immunomethods 1: 3-12). Using molecular design, biochemistry, and molecular biology techniques large proteins may be dissected to their smallest functional units. These approaches can be adapted for rational drug design and the development of agonists and antagonists. We developed mimics of antibodies (Science, 253:792), cellular receptors (Proc. Natl. Acad. Sci. (USA), 89:5872-5876), and polypeptide growth factors (antagonists, e.g. J. Biol. Chem., 270:6564-6569; and agonists e.g. Jour. Neuroscience 16: 1308-1316; Chem & Biol. 12:1015-28). The small molecule mimetic ligands are better in vivo at imaging and localizing tumors compared to mAbs (Nature Biotechnology, 14:1120-1122). Structural studies of these small molecule artificial ligands demonstrated that they adopt the predicted configurations (J. Med. Chem. 43: 3541-3548, Jour Biol Chem. 273:23652-23658). Pharmacological studies demonstrated that these small molecule designed agents can be useful as drugs or drug leads. We have succeeded in using these agents in various in vivo models of neurodegeneration (cognitive impairment in ageing, glaucoma) (J. Neurosci, 24:8009-18; J. Neurobiol. 58:341-54) and of cancer (Cancer Res. 2001 61:694-9). In vivo experimental cancer therapeutic studies have shown that our approaches improve the therapeutic index of useful (yet toxic) drugs by many fold, and more importantly help to by pass drug resistance (Oncogene 23:3613-21). Small molecules can be used to identify the relevant sites on receptors that can induce a biological response (Trends in Pharmacological Sciences 21: 93-98. Molec. Pharmacol. 57:385-391. Expert Opinion in Therapeutic Patents 9: 737-751). Using the small molecule ligands we can carry out fine studies of receptor biology (Jour Biol Chem. 275: 9946-9956. Proc. Natl. Acad. Sci. (USA) 96:4067-4072. Jour Biol Chem. 273: 34933-34940. Jour. Neuroscience 17: 6031-6037; J. Biol. Chem 276:1023-1029) such as studies of cross-regulation by different receptor activation sites, and biophysical analyses of ligand-receptor interactions. Recently we extended the concept of ligand mimicry to develop functional ligands of non-protein targets such as gangliosides. This is the first demonstration of a designed, synthetic, functional, small molecule ligand selective for a carbohydrate moiety, and builds on the recent conceptual breakthrough that gangliosides can be true functional cell surface receptors.

Schipper, Hyman

founding director of the Centre for Neurotranslational Research, a Biomedical Redox Laboratory and the Alzheimer Risk Assessment Clinic at the Jewish General Hospital, and a founding scientist of Molecular Biometrics Inc. Member of the Bloomfield Centre fEmail Website Publications

Alzheimer's Disease
Neurodegeneration
Parkinson's Disease
Schizophrenia

Biomarkers
Diagnostics
Oxidative stress
Animal models

Schweinhardt, Petra

Alan Edwards Centre for Research on PainEmail Website

Pain

Dopamine
Memory
Neuroimaging
Neurotransmitters
Psychopharmacology

Sebire, Guillaume

Director of Child Neurology Division, MCHEmail Publications

Autism
Basic Neuroscience
Encephalitis
Neuroprotection
Stroke

Animal models
Immune-neuro interactions
Cytokines
Developmental neuroimmunology
Materno-fetal inflammation
Neuroinflammation
Drug development
Prevention

Séguéla, Philippe

member, neural Circuits Res.Email Website Publications

Patents

License

Basic Neuroscience
Epilepsy
Pain
Stroke

Cell culture
Electrophysiology
Ion channels
Neural circuits
Neuronal circuits

Shah, Jai

Email Website Publications

Psychosis

Biomarkers
Neuroinflammation
Stress

Sharif Naeini, Reza

Email Website Publications

Patents

Mechanotransduction
Pain

Ion channels
Neural circuits
Neuronal circuits
Therapeutic

We are interested in understanding the molecular bases of mechanotransduction, and the role of mechanosensory neurons in normal and pathological pain transmission. Mechanotransduction, the process through which cells convert a mechanical stimulus into an electrical signal, is of fundamental importance to physiological functions such as our senses of touch (including pain) and hearing, as well as our ability to regulate our hydromineral homeostasis (thirst), baroreflex function and myogenic tone (regulation of blood pressure). Mechanosensitive ion channels are membrane proteins responsible for most mechanotransduction processes, yet their molecular identity has not been fully resolved. Because these channels are involved in several pathologies of the nervous (chronic pain, deafness) and cardiovascular (hypertension) systems, the molecular identification of these channels, and understanding their activation properties may lead to the development of new therapeutic strategies in several clinical areas. The projects in the lab focus on two areas of research: (1) Identification of the molecular mechanisms underlying neuronal mechanotransduction. and (2) Identification of central (spinal cord) neuronal circuits engaged by mechanosensory afferents in control or during chronic pain conditions.

Sharp, Madeleine

Email Website Publications

Cognitive Neuroscience
Parkinson's Disease

Clinical investigation
Dementia
Learning
Memory
Behaviour

Shevell, Michael

Lead Investigator of the Cerebral Palsy Demonstration Project of the NeuroDevNet Network of Centre of ExcellenceEmail Publications

Basic Neuroscience

Animal models
Cerebral palsy
Clinical investigation
Epidemiology
Neuroimaging
Newborn

Shmuel, Amir

Email Website Publications

Basic Neuroscience
Vision

Neuroimaging
Neurophysiology

Shoubridge, Eric

Email Website Publications

Basic Neuroscience

Genetics
Mitochondria

Shultz, Thomas

Associate Member of the School of Computer ScienceEmail Website Publications

Cognitive Neuroscience

Computational models
Development
Learning

Sinclair, David

Email Website

Basic Neuroscience
Neurosurgery
Stroke

Neural development
Neurosurgery
Stem cells
Therapeutics

Sonenberg, Nahum

Email Website Publications

Autism
Basic Neuroscience
Depression
Neurodevelopmental Disorders

Animal models
Therapeutics
Autism
Neuronal protein
Fragile-X syndrome

Sossin, Wayne

member, neural Circuits Res.Email Website Publications

Autism
Basic Neuroscience
Behavioural Neuroscience
Neurodevelopmental Disorders

Memory
Synapse
Electrophysiology
Signaling pathways
Molecular Neuroscience

Spreng, Nathan

Email Website Publications

Cognitive Neuroscience

Aging
Dementia
Executive functions
Memory
Neuroimaging

Srivastava, Lalit K.

Email Publications

Schizophrenia

Animal models
Dopamine
Genetics
Neurodevelopment

Srour, Myriam

Email Website Publications

Epilepsy
Neurodevelopmental disorders
Neurodevelopmental Disorders

Neuronal migration
Animal models
Genetics

My lab focuses on  deciphering of the genetic basis of childhood neurological disease, with a particular focus on disorders of structural brain abnormalities. Currently, the disorders studied include (1) focal cortical dysplasias (congenital brain malformation responsible for severe epilepsy), (2) schizencephaly (congenital brain malformation associated with variable developmental delay, cerebral palsy and epilepsy), and (3) congenital mirror movements (rare disorder in which affected individuals have involuntary movements on the oppositive side of their body mirroring their voluntary movements). Main technologies used will be whole exome sequencing. Biological validation of candidate genes is done using in-vitro and animal models. I am currently looking for a student to validate a candidate gene for Congenital Mirror Movements using the zebrafish animal model. Understanding the genetic basis of congenital movements allows the unraveling of the mechanisms underlying normal brain development and the crossing of neural fibers across the midline of the nervous system.

Steinhauer, Karsten

Psycholinguistics and Cognitive Neuroscience, Neurocognition of Language Lab.Email Website Publications

Cognitive Neuroscience

Language
Music
Neural circuits
Neuroimaging
Neuronal circuits
Speech perception

Stellwagen, David

Email Website Publications

Patents

Addiction
ALS
Autism
Huntington's disease
Neurodegeneration
Parkinson's Disease

Immune-neural interaction
TNF
Inflammation
Synapse

Stifani, Stefano

member of Brain Tumor GroupEmail Website Publications

ALS
Basic Neuroscience
Oncology

Motor neurons
Neural circuits
Neuronal circuits
Brain tumours
Neural development

Stone, Laura

Email Website Publications

Pain

Animal models
Diagnostics
Drug interactions
Electrophysiology
Genetics
Therapeutics behaviour

Storch, Florian

Email Website Publications

Basic Neuroscience

Animal models
Circadian rhythms
Genetics

The role of the multi-oscillator circadian timing system in physiology and behavior: By employing genetic dissection strategies we want to i) explore the biological significance of peripheral clocks located outside the suprachiasmatic nucleus (SCN) and ii) test the hypothesis that the SCN is functionally compartmentalized. It is believed that circadian clocks in the central nervous system play important roles in the control of various brain functions including the regulation of the sleep-wake cycle, locomotion, body weight, reproduction, and reward processing. We will rigorously examine these links by genetically manipulating clock function in selected brain structures as well as tissues and organs that are targets of neuroendocrine regulation such as the pituitary, gonads and adrenal glands. This research will likely yield fundamental insights in how our internal 24-hour timers effects the nervous system and may thus pave the way for new concepts to tackle mental disorders and other brain dysfunctions

Stratton, Jo Anne

Email Publications

Multiple Sclerosis

Animal models
Disease progression
Immune-neural interaction

Stroh, Thomas

supervises the MNI Microscopy Unit. This comprises common microscopic equipment of the MNI such as confocal microscopes, laser micromanipulation, and stereologic equipment.Email Website Publications

Basic Neuroscience

GPCR
Microscopy
Neuropharmacology
Somatostatin receptors

Sullivan, Michael

Centre for Research on Pain, Disability and Social Integration, Canada Research Chair in Behavioural HealthEmail

Cognitive Neuroscience
Pain

Disability
Predictors
Psychology

Suvrathan, Aparna

Email Website Website Publications

Autism
Basic Neuroscience

Synapse plasticity
Learning
Motor learning
Plasticity

Sziklas, Viviane

member, Epilepsy Res. GroupEmail Publications

Cognitive Neuroscience
Epilepsy

Animal models
Learning
Memory

Szyf, Moshe

co-founder, MethylgeneEmail Website Publications

Oncology

Therapeutic targets

Takahashi, Hideto

Director, Synapse Development and Plasticity research unitEmail Website Publications

Autism
Cognitive Neuroscience
Schizophrenia

Genetics
Learning
Memory
Plasticity
Synapse
Therapeutics

Tardif, Christine

Email Website Publications

Basic Neuroscience
Cognitive Neuroscience

Myelin
Neuroimaging
Computational models
Learning
Plasticity

Thiel, Alexander

Director of the Neuroplasticity Research Program at the Lady Davis Institute for Medical Research (LDI) and Director of the Stroke Unit at the Jewish General Hospital (JGH).Email Publications

Stroke

Microglia
Neuroimaging
Neuroplasticity
Rehabilitation
Therapeutics
Treatment

Trenholm, Stuart

Email Website Publications

Turecki, Gustavo

Director, McGill Group for Suicide Studies, Head, Depressive Disorders Program, Douglas InstituteEmail Website Publications

Depression
Suicide

Biomarkers
Environment
Epigenetics
Prevention
Treatment

Van Meyel, Donald

Centre for Research in NeuroscienceEmail Website Publications

Basic Neuroscience

Animal models
Axon
Dendrite
Genetics
Hedgehog
Immune-neural interaction
Neuroimaging

Van Raamsdonk, Jeremy

Email Website Publications

Aging
Genetics
Huntington's Disease
Neuroprotection
Parkinson's Disease

Oxidative Stress
C. elegans
Mitochondria
Neurodegenerative Disease
Animal models

Velly, Ana

Email Website Publications

Clinical epidemiology

Adverse events related to the management of chronic pain
Biomarkers of pain
Epidemiology of acute and chronic pain
Management of Chronic Pain
Transition from acute to chronic pain

Villeneuve, Sylvia

Email Website Publications

Alzheimer's Disease

Amyloid
Biomarkers
Neuroimaging
Neuropsychology
Risk factor
Tau
Therapeutics

Vollrath, Melissa

Associate Prof. Exp. MedEmail Publications

Basic Neuroscience

Animal models
Ion channels
Sensory neurobiology

Walker, Claire-Dominique

Director, Neuroscience Research Division, Douglas InstituteEmail Publications

Basic Neuroscience
Stress

Endocannabinoids
Environment
Maternal behaviour
Plasticity
Development
Food intake

Watt, Alanna

Email Website Publications

Basic Neuroscience
Neurodegeneration

Aging
Animal models
Ataxia
Electrophysiology
Imaging
Motor behaviour
Neural circuits

Williams, Sylvain

Electrophysiology, theta and gamma rhythms, hippocampus, optogenetics.Email Website Publications

Alzheimer's Disease
Cognitive Neuroscience
Schizophrenia

In vitro assay
Learning
Memory
Neural circuits
Neuronal circuits
Electrophysiology

Wing, Simon

Email Website Publications

Wintermark, Pia

Pediatrician and Neonatologist, MCH & RVH Director, NeobrainlabEmail Website Website Publications

Basic Neuroscience
Neuroinflammation
Stroke
Vision

Animal models
Asphyxia
Brain blood flow
Diagnostics
Eeg
Neonatal
Neuroimaging
Therapeutics
EEG

Wolfson, Christina

co-lead on a national study on aging, The Canadian Longitudinal Study on Aging, - appointed McGill’s new Deputy Research Integrity Officer, commencing on January 1, 2016. Effective June 1, 2016, Dr. Wolfson will become McGill’s Research Integrity OffiEmail Publications

Multiple Sclerosis
Parkinson's Disease

Risk factors
Disease course
Therapeutic target

Woolley, Sarah

Email Website

Cognitive Neuroscience

Animal models
Behaviour
Communication
Computational models
Electrophysiology
Learning

Zatorre, Robert

member, Cognitive NS groupEmail Publications

Cognitive Neuroscience
Hearing

Language
Music
Neuroimaging

Zhang, Ji

Email Website

Pain

Animal models
Behaviour
Immune-neural interaction
Therapeutic

Zhang, Tie Yuan

Email Website Publications

Cellular Neuroscience
Depression
Stress

Optogenetics
Animal models
Epigenetics
Maternal care

Zhou, Yang

Email Publications

Basic Neuroscience
Neurodevelopmental disorders
Neurodevelopmental Disorders

Therapeutics
Animal models
Molecular Neuroscience

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