MONTREAL NEUROLOGICAL INSTITUTE MEMBERS
McGILL UNIVERSITY PUBLICATIONS

 

Eliane Kobayashi, MD, PhD

Dr. Kobayashi obtained her medical degree in Campinas, Brazil, where she also completed the neurology residency program, epilepsy fellowship and PhD studies (Familial temporal lobe epilepsy: clinical aspects and MRI findings).

She came to the MNI in 2003 for a postdoctoral fellowship with Dr. Gotman and Dr. Dubeau. Her postdoctoral project aimed to study the relationships between lesions and activations in EEG-fMRI and was supported by the Preston Robb fellowship and by a CIHR postdoctoral fellowship.

Since 2007 she is an Assistant Professor at the Department of Neurology and Neurosurgery.  In addition, she also works as a clinical neurologist and neurophysiologist at the MNI Epilepsy Service.

 

Her main research and clinical interests include:
(1) genotype-phenotype correlation in familial epilepsies, to understand how the genetic basis influence the clinical presentation and structural/functional abnormalities in patients with inherited forms of epilepsy, especially temporal lobe epilepsies:
(2) application of multimodal neurophysiology, structural and functional neuroimaging for the evaluation of propagation of epileptic activity and the extent of the epileptogenic network (magnetoencephalography/magnetic source imaging, combined recording of electroencephalogram and functional magnetic resonance imaging, magnetic resonance spectroscopy:
(3) understanding the mechanisms underlying hyperexcitability in epilepsy and their relationship with seizure vulnerability and seizure intractability (using receptor binding studies with positron emission tomography, autoradiography, immunohistochemistry and gene expression studies). 

  Email: eliane.kobayashi@mcgill.ca

  MNI webpage

 

Address:

 

Montreal Neurological Institute

3801 University Street

room 125

H3A 2B4 Montreal

 

 

Phone number:            

 

Office:  (514) 398 6644, ext 00469

Fax: 514-398-8106 

Collaborators:


 Current funding:

 

Publications:

 

Yu JM, Tyvaert L, Zelmann R, Dubeau F, Gotman J, Kobayashi E. EEG spectral changes underlying BOLD responses contralateral to spikes in patients with focal epilepsy. Epilepsia 2009 Apr 6. [Epub ahead of print].

 

 Kobayashi E, Grova C, Tyvaert L, Dubeau F, Gotman J. Structures Involved at the Time of Temporal Lobe Spikes Revealed by Inter-Individual Group Analysis of EEG/fMRI Data. Epilepsia 2009 Jun 22. [Epub ahead of print].

 

 Moeller F, Tyvaert L, Nguyen DK, Bouthillier A, Kobayashi E, Tampieri D, Dubeau F, Gotman J. EEG-fMRI: a promising technique for evaluating patients with non lesional frontal lobe epilepsy. Neurology 2009, in press.

 

Tyvaert L, Hawco C, Kobayashi E, LeVan P, Dubeau F, Gotman J. Difference between ictal and interictal generators in malformations of cortical development studied with EEG-fMRI. Brain 2008 Jul 16. [Epub ahead of print]

 

Grova C, Daunizeau J, Kobayashi E, Bagshaw AP, Lina JM, Dubeau F, Gotman J. Concordance between distributed EEG source localization and simultaneous EEG-fMRI studies of epileptic spikes. Neuroimage 2008 Jan 15;39(2):755-74. Epub 2007 Aug 25. 

 

Jacobs J, Rohr A, Moeller F, Boor R, Kobayashi E, LeVan P, Stephani U, Gotman J, Siniatchkin M. Evaluation of epileptogenic networks in children with Tuberous Sclerosis Complex using EEG-fMRI. Epilepsia 2008 Jan 2; [Epub ahead of print]

 

Jacobs J, Hawco C, Kobayashi E, Boor R, LeVan P, Ulrich S, Siniatchkin M, Gotman J. Variability of the hemodynamic response as a function of age and frequency of epileptic discharge in children with epilepsy. Neuroimage 2008 Apr 1;40(2):601-14. Epub 2007 Dec 15.

 

Jacobs J, Kobayashi E, Boor R, Muhle H, Wolff S, Hawco C, Dubeau F, Jansen O, Stephani U, Gotman J, Siniatchkin M. Hemodynamic responses to interictal epileptiform discharges in children with symptomatic epilepsy. Epilepsia 2007 Nov;48(11):2068-78.

 

Kobayashi E, Bagshaw AP, Gotman J, Dubeau F. Metabolic correlates of epileptic spikes in cerebral cavernous angiomas. Epilepsy Res. 2007 Jan;73(1):98-103.

 

Bagshaw AP, Torab L, Kobayashi E, Hawco C, Dubeau F, Pike GB, Gotman J. EEG-fMRI using Z-shimming in Patients with Temporal Lobe Epilepsy. In press, J Magn Reson Imaging.

 

Lu Y, Bagshaw AP, Grova C, Kobayashi E, Dubeau F, Gotman J. Using voxel-specific hemodynamic response function in EEG-fMRI data analysis. Neuroimage. 2006 Aug 1;32(1):238-47. Epub 2006 Jun 13.


Gotman J, Kobayashi E, Bagshaw AP, Benar CG, Dubeau F. Combining EEG and fMRI: a multimodal tool for epilepsy research. J Magn Reson Imaging. 2006 Jun;23(6):906-20.

Kobayashi E, Hawco CS, Grova C, Dubeau F, Gotman J. Widespread and intense BOLD changes during brief focal electrographic seizures. Neurology. 2006 Apr 11;66(7):1049-55.

Kobayashi E, Bagshaw AP, Benar CG, Aghakhani Y, Andermann F, Dubeau F, Gotman J. Temporal and extratemporal BOLD responses to temporal lobe interictal spikes. Epilepsia. 2006 Feb;47(2):343-54.

Kobayashi E, Bagshaw AP, Grova C, Gotman J, Dubeau F. Grey Matter Heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. Brain 2006 Feb;129(Pt 2):366-74. Epub 2005 Dec 9.

Bénar CG, Grova C, Kobayashi E, Bagshaw AP, Aghakhani Y, Dubeau F, Gotman J. EEG-fMRI of Epileptic Spikes: Concordance with EEG Source Localization and Intracranial EEG. NeuroImage, 2006 Jan 11; [Epub ahead of print]

Aghakhani Y, Kobayashi E, Bagshaw AP, Hawco C, Bénar CG, Dubeau F, Gotman J. Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikes. Clin Neurophysiol 2006 Jan;117(1):177-91. Epub 2005 Nov 28.

Cendes F, Kobayashi E, Lopes-Cendes I. Familial temporal lobe epilepsy with auditory features. Epilepsia 2005;46 Suppl 10:59-60.

Andermann F, Kobayashi E, Andermann E. Genetic focal epilepsies: state of the art and paths to the future. Epilepsia 2005;46 Suppl 10:61-7.

Kobayashi E, Thomas P, Andermann F. Tonic status epilepticus in patients with idiopathic generalized epilepsy. Epileptic Disord 2005 Dec;7(4):327-3.

Bagshaw AP, Kobayashi E, Dubeau F, Pike GB and Gotman J. Correspondence between EEG-fMRI and EEG dipole localisation of interictal discharges in focal epilepsy. Neuroimage, 2005 Oct 31; [Epub ahead of print].

Gotman J, Grova C, Bagshaw AP, Kobayashi E, Aghakhani Y, Dubeau F. Generalized Epileptic Discharges: Thalamo-cortical Activation and Suspension of the Default State of the Brain. Proc Natl Acad Sci U S A 2005 Oct 18;102(42):15236-40. Epub 2005 Oct 10.

Stefanovic B, Warnking JM, Kobayashi E, Bagshaw AP, Hawco C, Dubeau F, Gotman J, Pike GB. Hemodynamic and Metabolic Responses to Activation, Deactivation and Epileptic Discharges. Neuroimage 2005 Oct 15;28(1):205-15. Epub 2005 Jul 5.

Kobayashi E, Bagshaw AP, Grova C, Dubeau F, Gotman J. Negative BOLD responses to epileptic spikes. Hum Brain Mapp 2005 Sep 22; [Epub ahead of print].

Kobayashi E, Bagshaw A, Jansen A, Andermann F, Andermann E, Gotman J, Dubeau F. Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses. Neurology, 64:1263-1266, 2005.


da Gama CN, Kobayashi E, Li M Li, Cendes F. Hippocampal atrophy and neurocysticercosis calcifications. Seizure 2005 Mar;14(2):85-8.

Bagshaw AP, Hawco C, Bénar CG, Kobayashi E, Aghakhani Y, Dubeau F, Pike GB, Gotman J. Analysis of the EEG-fMRI response to prolonged bursts of interictal epileptiform activity. Neuroimage 2005 Feb 15;24(4):1099-112.

Alessio A, Kobayashi E, Damasceno BP, Lopes-Cendes I, Cendes F. Evidence of memory impairment in asymptomatic individuals with hippocampal atrophy. Epilepsy Behav 2004 Dec;5(6):981-7.

Ferreira FT, Kobayashi E, Lopes-Cendes I, Cendes F. Structural abnormalities are similar in familial and nonfamilial mesial temporal lobe epilepsy. Can J Neurol Sci 2004 Aug;31(3):368-72.

Bagshaw AP, Agha Khani Y, Bénar CG, Kobayashi E, Hawco C, Dubeau F, Pike GB, Gotman J. EEG-fMRI of focal epileptic spikes: analysis with multiple haemodynamic functions and comparison with gadolinium-enhanced MR angiograms. Hum Brain Mapp 2004 Jul;22(3):179-192.

Bonilha L, Kobayashi E, Li M Li, Cendes F. Protocol for volumetric segmentation of medial temporal structures using high-resolution 3-D magnetic resonance imaging. Hum Brain Mapp 2004 Jun;22(2):145-54.

Alessio A, Damasceno BP, Camargo CH, Kobayashi E, Guerreiro CA, Cendes F. Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy. Epilepsy Behav 2004 Feb;5(1):22-7.

Bonilha L, Kobayashi E, Rorden C, Cendes F, Li M Li. Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 2003 Dec;74(12):1627-1630.

 Bonilha L, Kobayashi E, Castellano G, Coelho G, Tinois E, Cendes F, Li M Li. Texture analysis of hippocampal sclerosis. Epilepsia 2003 Dec;44(12):1-5.

Kobayashi E, Santos NF, Torres FR, Secolin R, Sardinha LAF, Lopes-Cendes I, Cendes F. MRI abnormalities in familial temporal lobe epilepsy with auditory auras and linkage to chromosome 10q. Arch Neurol 2003 Nov;60(11):1546-1551.

Kobayashi E, D’Agostino MD, Lopes-Cendes I, Andermann E, Dubeau F, Guerreiro CAM, Schenka AA, Queiroz LS, Olivier A, Cendes F, Andermann F. Outcome of surgical treatment in patients with familial mesial temporal lobe epilepsy. Epilepsia 2003 Aug; 44(8):1079-1083.

Bonilha L, Kobayashi E, CendesF, Li M Li. Effects of method and MRI slice thickness on entorhinal cortex volumetry. NeuroReport 2003 Jul; 14(10):1291-1295.

Coan AC, Kobayashi E, Lopes-Cendes I, Li M Li, Cendes F. Quantification of hippocampal signal intensity in patients with mesial temporal lobe epilepsy. J Neuroimaging 2003 Jul;13(3):228-33.

de Marco FA, Ghizoni E, Kobayashi E, Cendes F. Cerebelar volume and long term use of phenytoin: MRI volumetric studies. Seizure 2003 Jul;12(5):312-315.

Kobayashi E, D’Agostino MD, Lopes-Cendes I, Berkovic SF, Li M Li, Andermann E, Andermann F, Cendes F. Hippocampal atrophy and T2 weighted signal changes in familial mesial temporal lobe epilepsy. Neurology 2003 Feb 11;60(3):405-9.

Kobayashi E, Li LM, Lopes-Cendes I, Cendes F. Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsy. Arch Neurol 2002 Dec;59(12):1891-4.

Kobayashi E, Facchin D, Steiner CE, Leone AAA, Campos NLV, Cendes F, Lopes-Cendes I. Mesial temporal lobe abnormalities in a family with 15q26qter trisomy. Arch Neurol 2002 Sep;59(9):1476-9.

Guerreiro CA, Montenegro MA, Kobayashi E, Noronha AL, Guerreiro MM, Cendes F. Daytime outpatient versus inpatient video-EEG monitoring for presurgical evaluation in temporal lobe epilepsy. J Clin Neurophysiol 2002 Jun;19(3):204-8.


Kobayashi E, Sousa SC, Lopes-Cendes I, Guerreiro CAM, Guerreiro MM, Cendes F. Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy. Neurology 2001Jan 23;56(2):166-172.
 

 

Chapters:

 

Kobayashi E, Andermann F, Andermann E. Familial focal epilepsy with variable foci. In: Engel J, Pedley TA, editors. Epilepsy: A Comprehensive Textbook, 2nd edition. 2008; 2549-2552. Lippincott Williams and Wilkins, Philadelphia.  
 

Cendes F, Kobayashi E, Lopes-Cendes I, Andermann E, Andermann F. Familial temporal lobe epilepsy. In: Engel J, Pedley TA, editors. Epilepsy: A Comprehensive Textbook, 2nd edition. 2008; 2487-2494. Lippincott Williams and Wilkins, Philadelphia.  
 

Kobayashi E, Zifkin B, Andermann F, Andermann E. Juvenile myoclonic epilepsy. In: Engel J, Pedley TA, editors. Epilepsy: A Comprehensive Textbook, 2nd edition. 2008; 2455-2450. Lippincott Williams and Wilkins, Philadelphia.  
 

Kobayashi E, Andermann E, Andermann F, Scheffer I. Is there a subset of benign cases within the autosomal dominant focal epilepsies? In: Fejerman N, Caraballo RH, editors. Benign focal epilepsies in infancy, childhood and adolescence. Current problems in epilepsy series: vol 21. John Libbey Eurotext, Montrouge, France. 2007: 255-266.  
 

Cendes F, Kobayashi E. Epilepsia de lobo temporal.

In: Guerreiro CAM, Guerreiro MM, Cendes F, Lopes-Cendes I (Eds). Epilepsia, 3a edição. São Paulo: Lemos editorial, 2000:201-214.

Kobayashi E, Andermann F, Andermann E. Familial mesial temporal lobe epilepsy.

In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. Available at www.medlink.com.

Kobayashi E, Andermann F, Andermann E. Familial lateral temporal lobe epilepsy.
In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. Available at www.medlink.com.

Kobayashi E, Andermann F, Andermann E. Familial partial epilepsy with variable foci.
In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. Available at www.medlink.com.