Integrated Program in Neuroscience Home Page | Integrated Program in Neuroscience

Antel, Jack

Rotation Program

group leader, NeuroImm. Res. GroupEmail Website Publications

Multiple Sclerosis

Immune-neural interaction
Inflammation

Archambault, Philippe

Rotation Program

Email Website Publications

Basic Neuroscience
Physical Disabilities

Motor learning
Rehabilitation
Robotics
Virtual reality
Wheelchair

Audrain, Sam

Rotation Program

Email Website Publications

Cognitive Neuroscience
Epilepsy
Sleep

Memory
Neuroimaging
MRI
Neuropsychology

Bagot, Rosemary

Rotation Program

Email Publications

Depression

Animal models
Behaviour
Electrophysiology
Genetics

Baillet, Sylvain

Rotation Program

contributed image analysis techniques for the early prediction of infarct growth in stroke, with diffusion-weighted MRI and innovative image analysis methods. These latter have been successfully transferred to the biomedical imaging industry. Group LeaderEmail Website Publications

Cognitive Neuroscience

Clinical investigation
Computational models
Neuroimaging
Treatment

Sylvain Baillet is a physicist with research interests in methodological developments for functional and structural brain imaging and their application to clinical and cognitive Neuroscience. Although his primary expertise is with MEG (magnetoencephalography) imaging, he also contributed new techniques for MRI image segmentation and inter-subject registration. He has also initiated new image analysis techniques for the early prediction of infarct growth in stroke patients, using diffusion-weighted MR sequences. His current research projects with MEG include real-time therapeutic imaging, the evaluation of resting-state brain activity and connectivity in the healthy and diseased brain, and the development of original data mining and visualization techniques for time-resolved brain image series. He has also great interest in disseminating his research through academic software: he is a founding developer of the Brainstorm open-source software project (http://neuroimage.usc.edu/brainstorm) for MEG and EEG imaging with MRI integration.

Baldwin, Alex

Rotation Program

Email Website Publications

Cognitive Neuroscience
Vision

Binocular vision
Behaviour
Modeling
Perception
Psychophysics

Barnett, Alex

Rotation Program

Email Website Publications

Cognitive Neuroscience
Epilepsy

Memory
Neuroimaging
Cognition

Bashivan, Pouya

Rotation Program

Email Website Publications

Cognitive Neuroscience
Vision

Computational models
Memory
Behaviour
Perception

Baum, Shari

Rotation Program

Email Website Publications

Cognitive Neuroscience

Behaviour
Language
Neuroimaging
Speech

Bechstedt, Susanne

Rotation Program

Email Website Publications

Basic Neuroscience
Cellular Neuroscience
Neurodegeneration

Cell culture
Microtubule
Microscopy
In vitro assay
Prion protein

Benrimoh, David

Rotation Program

Email Website Publications

Cognitive Neuroscience
Mental Health
Psychosis
Schizophrenia

Computational models
Modeling
Psychosis
Neuroimaging
Psychiatry

David Benrimoh is a neuropsychiatrist who completed his psychiatry residency at McGill. He received an MSc. in Neuroscience from UCL, working with Karl Friston on computational models of auditory hallucinations. He received a second MSc. in Psychiatry from McGill, working with Simon Ducharme and Bratislav Misic on transdiagnostic imaging in psychosis. He is the founder and chief science officer at Aifred Health, a digital mental health company using artificial intelligence to create decision support tools for mental health clinicians; Aifred won the $1M USD second place prize in the global IBM-sponsored AI XPRIZE. He completed his fellowship in Neuropsychiatry at Stanford University, where he conducted research on the mechanistic underpinnings of rapid acting rTMS. His research lab, the McGill Lab for Computational Psychiatry and Translation (McPsyt), focuses on computational psychiatry approaches to understanding and predicting psychosis onset and using this knowledge to develop novel treatment paradigms using rTMS.

Beraldo Meloto, Carolina

Rotation Program

Email Publications

Clinical epidemiology
Pain

Transition from acute to chronic pain
Axon guidance
Chronic pain
Clinical investigation
Genetics
Predictors

Bernard, Daniel

Rotation Program

Email Website Publications

Basic Neuroscience

Hormones
In vitro assay
In vivo assay
Signaling pathways

Bernhardt, Boris

Rotation Program

Email Website Publications

Autism
Epilepsy

Behaviour
Biomarkers
Diagnostics
Neuroimaging

Bertone, Armando

Rotation Program

director of the Perceptual Neuroscience Laboratory for Autism and Development (PNLab)Email Website Publications

Autism
Cognitive Neuroscience

Behaviour
Development
Diagnostics
Neuropsychology
Perception

Boudrias, Marie-Hélène

Rotation Program

Email Website Publications

Aging
Stroke

Biomarkers
Electrophysiology
Motor function
Neuroimaging

Bourque, Charles

Rotation Program

Centre for Research in NeuroscienceEmail Website Publications

Basic Neuroscience

Immune-neural interaction
Ion channels
Osmoreceptors

Bouvier, Liziane

Rotation Program

Email Website Publications

ALS
Cognitive Neuroscience
Dementia

Diagnostics
Language
Speech
Speech motor disorders

Bowie, Derek

Rotation Program

Director of the FRQS-funded research group, GEPROMEmail Website Publications

ADHD
Ataxia
Autism
Basic Neuroscience
Down syndrome
Epilepsy
Hyperactivity
Mental Disorder
Stroke
Vision

Electrophysiology
Gaba-a
Glutamatergic systems
Ion channels
Mental retardation
Neurodevelopment
Receptors
Structural biology
Synapse plasticity
Therapeutics targets
GABA-A

Brais, Bernard

Rotation Program

group leader, Rare Neurol. Dis. co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital, and Director of the CHUM ataxia centreEmail Website Publications

Patents

License

Ataxia
Leukodystrophies
Leukoencephalopathies
Musucular Dystrophies
Myopathies
Sensory and Autonomic Neuropathies

Cerebellar pathology
Genetics
Muscle pathology
Population genetics
Transgenic mice models

Brandon, Mark

Rotation Program

Email Website Publications

Cognitive Neuroscience

Electrophysiology
Optogenetics

Braverman, Nancy

Rotation Program

Email Publications

Britt, Jonathan

Rotation Program

Email Website Publications

Addiction
Cognitive Neuroscience
OCD
Tourette's Syndrome

Animal models
Drug abuse
Electrophysiology
Optogenetics
Behaviour
Learning
Neural circuits
Neuronal circuits

Brunet, Alain

Rotation Program

Director, Psychosocial Research DivisionEmail Website Publications

PTSD

Assessment
Risk factors
Treatment

Cayouette, Michel

Rotation Program

director of the Cellular Neurobiology LaboratoryEmail Website Publications

Alzheimer's Disease
Neurodegeneration
Parkinson's Disease
Vision

Genetics
Retina
Stem cells

Cermakian, Nicolas

Rotation Program

Director, Laboratory of Molecular ChronobiologyEmail Website Publications

Basic Neuroscience
Infections
Sleep

Animal models
Immune-neural interaction
Circadian rhythms
Genetics
Immune response
Phototherapy

Chacron, Maurice

Rotation Program

Computational Systems Neuroscience LaboratoryEmail Website Publications

Basic Neuroscience

Animal models
Behaviour
Electrophysiology
Modeling
Sensory processing

Chai, Xiaoqian

Rotation Program

Email Website Publications

Cognitive Neuroscience

Development
Language
Memory
Neuroimaging

Chakravarty, Mallar

Rotation Program

leads the Computational Brain Anatomy (CoBrA) Laboratory at the Brain Imaging Centre.Email Website Publications

Basic Neuroscience

Brain anatomy
Computational models
Neuroimaging

Magnetic resonance imaging (MRI) is one of the tools of choice for the analysis of the brain in normally functioning and diseased states. Different MRI acquisition protocols provide excellent contrast and resolution and can be analyzed using automated techniques. The goal of Dr. Chakravarty’s work is to develop and use computational neuroanatomical techniques to understand how the structure of the brain is altered in psychiatric disorders. These techniques include the automated identification of structures and computational metrics that quantify their shape.  He is currently working on adding information from diffusion tensor imaging in order to describe inter-structural connectivity.  Many of these techniques can be used to elucidate phenotypes that can help describe brain risk for the major psychosis or pathological ageing.  To date, Dr. Chakravarty and the Computational Brain Anatomy (CoBrA) Laboratory have been using these techniques to better understand the alterations in brain anatomy that underly the major psychoses, ageing, brain development, and Alzheimer's disease.

Charron, Frederic

Rotation Program

director of the Molecular Biology of Neural Development Laboratory at the Université de Montréal and affiliated with McGill University.Email Website Publications

Basic Neuroscience

Axon
Genetics
Hedgehog
Neural circuits
Neuroimaging
Neuronal circuits

Chen, Brian

Rotation Program

Email Website Publications

Patents

License

Basic Neuroscience

Animal models
Dscam receptors
Genetics
Neural circuits
Neuroimaging
Neuronal circuits

Clarke, Paul

Rotation Program

Email Website Publications

Behavioural neuroscience

Amphetamine
Animal behaviour
Animal models
Cocaine
Dopamine
Nicotine
Nicotinic cholinergic receptors
Noradrenaline
Opioids

Cléry, Justine

Rotation Program

Email Website Publications

Behavioural neuroscience
Cognitive Neuroscience
Neurodevelopmental disorders

Animal models
Neuroimaging
Sensory function
Social interaction

Cloutier, Jean-Francois

Rotation Program

Member, Neural circuits Res.Email Website Publications

Basic Neuroscience

Animal models
Axon
Regeneration
Therapeutics

Dr. Jean-François Cloutier’s research is aimed at understanding the molecular mechanisms that control axonal pathfinding during development of the nervous systems. The formation of accurate connections between the peripheral and central nervous systems is essential for the functioning of the various sensory systems that allow us to detect odors, sounds, tastes, pain, and temperature. While the basic anatomical principles of wiring in these systems are well understood, little is known about the mechanisms involved in establishing these wiring patterns.

Dr.Cloutier uses a combination of in vivo mouse genetic models and molecular biological approaches to identify cues involved in guiding axons of primary sensory neurons to their targets and to characterize intracellular signals that function downstream of these axon guidance cues. Gaining insight into the basic mode of action of guidance molecules will be important in the future development of therapies for neurological disorders and injuries requiring regeneration of specific axonal connections.

Collins, Louis

Rotation Program

Joint Appointment in BioMedical Engineering -member, NeuroImaging & Neuroinform Res.Email Website Publications

Patents

License

Basic Neuroscience

Neuroimaging
Neuroinformatics
Treatment

Cooper, Ellis

Rotation Program

Email Website

Basic Neuroscience

Animal models
Electrophysiology
Neural circuits
Neuronal circuits
Synapse

Couturier, Charles

Rotation Program

Email Publications

Basic Neuroscience
Genomics
Oncology
Single-Cell Genomics

Brain tumours
Immunity
Oncology
Neuroimaging
Computational Modeling

Dadar, Mahsa

Rotation Program

Email Website Publications

Aging
Basic Neuroscience
Cognitive Neuroscience
Dementia
Neurodegeneration

Brain and Cognitive Changes
Neuroinformatics
Modeling
Neuroimaging
Biomarkers

Dagher, Alain

Rotation Program

neurologist specializing in movement disorders and functional brain imaging. Member, Neuroimaging & Neuroinform.Email Publications

Addiction
Eating Disorders
Parkinson's Disease
Stress

Basal ganglia
Dopamine
Neuroimaging
Neurotransmitters

de Villers-Sidani, Etienne

Rotation Program

member, neural Circuits Res.Email Publications

Cognitive Neuroscience
Hearing

Electrophysiology
Sensory-motor processing
Therapeutics

Ding, Jun

Rotation Program

Email Website Publications

Bioinformatics
Machine Learning
Single-Cell Genomics

Genetics
Health Informatics
Computational Modeling

Our lab focuses on studying cell dynamics in various biological processes in many diseases (e.g., developmental disorder, pulmonary diseases, cancers). Decoding cell dynamics is essential for understanding the pathogenesis of diseases and finding novel therapeutics. The existence of enormous heterogeneity in those diseases makes it challenging to decipher the unknown. The advancing single-cell technologies that profile individual cell states provide unprecedented opportunities to tackle this problem, which could drive biological discoveries and medical innovations in various fields (such as developmental and cancer biology). However, the single-cell data presents numerous new challenges in developing computational models that bridge the biomedical data and potential discoveries. Our primary research is to develop machine learning approaches (particularly probabilistic graphical models) to jointly analyze, model, and visualize single-cell (and/or bulk) omics data (preferably longitudinal or spatial). Such computational models will be used to help us derive a deeper understanding of the cell dynamics in different biological systems, which will eventually benefit the public health with machine-learning driven new diagnostic and therapeutic strategies.

Ducharme, Simon

Rotation Program

Email Website Publications

Aging
Alzheimer's Disease
Dementia
Epilepsy
Neurodegeneration

Biomarkers
Neuroimaging
Clinical trials

Durandau, Guillaume

Rotation Program

Email Website Publications Publications

Aging
Basic Neuroscience
Machine Learning
Physical Disabilities
Stroke

Biomechanics
Rehabilitation
Muscle
Robotics
Deep Learning

El Mestikawy, Salah

Rotation Program

Email Website

Basic Neuroscience

Animal models
Biomarkers
Diagnostics
Glutamergic systems
Neurotransmitters
Therapeutics

Elsabbagh, Mayada

Rotation Program

manages the Knowledge Translation portfolio for NeuroDevNet, a Canadian national Network of Center’s of Excellence.MHC _ R&TEmail Website Publications

Autism

Behaviour
Childhood
EEG
Genetics

Ernst, Carl

Rotation Program

Email Website Publications

Mental Disorder

Behaviour
Cellular models
Genetics
Screening assay
Stem cells

Evans, Alan

Rotation Program

member, NeuroImaging & Neuroinform Res.Email Publications

Cognitive Neuroscience

Language
Memory
Neuroimaging
Neuroinformatics

Farivar, Reza

Rotation Program

Patents

TBI
Vision

Diagnostics
Neuroimaging
Animal models

Fellows, Lesley

Rotation Program

neurologist specializing in disorders of cognition Group leader, Cognitive NSEmail Publications

Cognitive Neuroscience

Frontal lobe
Neurochemistry

Ferrari, Manuela

Rotation Program

Email Website

Mental Health
Psychosis

Mental Health Services
Psychiatry
Psychosis
Prevention
Services
Social determinant

Flores, Cecilia

Rotation Program

Email Website Publications

Addiction
Depression
Mental Disorder
Neurodevelopmental disorders

Animal models
Susceptibility
Biomarkers

Fon, Edward

Rotation Program

Director of the McGill Parkinson Program. Group leader Neurodeg. Disorder Res.Email Publications

Parkinson's Disease

Neurotransmitters
Therapeutics
Ubiquitin

Fournier, Alyson

Rotation Program

member, neurodeg. Disorder Res.Email Website Publications

Basic Neuroscience

Cytoskeleton
Neurite outgrowth
Regeneration

Gan-Or, Ziv

Rotation Program

Email Publications

Parkinson's Disease
Sleep

Alpha synuclein
Behaviour
Genetics

Garzia, Livia

Rotation Program

Email Publications

Genomics
Oncology

Oncology
Animal models
Brain tumours
Epigenetics
Genetics

Geddes, Maiya

Rotation Program

Email Website

Alzheimer's Disease
Cognitive Neuroscience
Mental Health

Neuropsychology
Aging
Decision making
Neuroimaging
Behaviour

Giros, Bruno

Rotation Program

Director, Schizophrenia and neurodevelopmental disorders research themeEmail Website Publications

Depression
PTSD
Schizophrenia

Animal models
Pre-clinical research
Signalization
Therapeutic
Translational
Neurotransmitters
Psychopharmacology

Gold, Ian

Rotation Program

in Division of social and transcultural PsychiatryEmail Website

Mental Disorder

Cultural psychiatry
Delusion

Gratton, Alain

Rotation Program

Email Website Publications

Addiction
Stress

Neurochemistry
Neurotransmitters
Psychopharmacology
Voltammetry
Neurodevelopment factors

The main focus of my research is on the brain circuitry that controls how we cope with stressors and its role in drug addiction. I am currently interested in the medial prefrontal cortex (PFC), a brain region that reaches its full development during late adolescence/early adulthood.  This brain region controls several complexe tasks such as decision-making and planning and has been implicated in the compulsive behavior of drug addicts.  In part because it matures slowly, the PFC is particularly vulnerable to insults which can cause it to develop abnormally and lead to maladaptive behavior. The PFC is also extremely sensitive to stressors and plays an important role in mounting the appropriate coping responses. The neurotransmitters, dopamine and glutamate, have been implicated in PFC-mediated coping responses to stressors and actions of addictive drugs.  For our studies we use voltammetry and microsensors to monitor, in behaving rats, minute changes in dopamine and glutamate transmission on a second-to-second basis.

Harnad, Stevan

Rotation Program

affiliated at McGill, Canada Research Chair in Cognitive Sciences Primary Appointment at UQAMEmail Website Publications

Cognitive Neuroscience

Computational models
Language
Learning

Harroud, Adil

Rotation Program

Email Website Publications

Genomics
Multiple Sclerosis

Genetics
Epidemiology
Risk factors

Hazrati, Lili-Naz

Rotation Program

Email Website

Alzheimer's Disease
Basic Neuroscience
Neurodegeneration
TBI

Tau
Cell senescence
Inflammation
Athletes
Concussion

Hendricks, Adam

Rotation Program

Dual Master's Program

Primary appointment in BioengineeeringEmail Website Publications

Neurodegeneration

Animal models
Behaviour
Cell assay
Engineering
In vitro assay
Motor protein

Many essential cellular functions including cell division, motility, protein synthesis, and intracellular transport are driven by motor proteins, a specialized set of enzymes that convert chemical energy into mechanical work. Two motor proteins, kinesin and cytoplasmic dynein, are responsible for the long-range transport of mRNA, proteins, organelles, and signaling molecules along the microtubule cytoskeleton. Active transport by kinesin and dynein is critical for the maintenance of biosynthetic, signaling, and degradative pathways in the cell. Long and highly-polarized cells like neurons are particularly sensitive, and accordingly mutations in kinesin or dynein cause neurodegenerative disease in mouse models and humans. Further, defects in intracellular transport have been linked to many neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, and Huntington’s disease.

In the complex cellular environment, kinesin and dynein are regulated by interactions with the cytoskeleton, other motor proteins, and binding partners. These interactions allow motors to perform complicated functions such as cell division and the targeted trafficking of intracellular cargoes. The Hendricks lab is focused on understanding how motor proteins function collectively, and how interactions among motor proteins and with the complex cellular environment modulate their behavior. We employ in vitro experiments that incorporate aspects of the cellular environment, high-resolution tracking and manipulation in living cells, and mathematical modeling to understand motor protein dynamics in the cell. In particular, we aim to develop methods to extend the application of single molecule techniques such as optical trapping, FRET, and subpixel resolution tracking to examine motor function in living cells.

Hendricks, Michael

Rotation Program

Email Website Publications

Basic Neuroscience

Animal models
Behaviour
Neural circuits
Neuroimaging
Neuronal circuits

Hess, Robert

Rotation Program

Director, McGill Vision ResearchEmail Website Publications

License

Vision

Amblyopia
Motion
Neuroimaging
Space
Video game

Jahani-Asl, Arezu

Rotation Program

Email Website Publications

Basic Neuroscience

Brain tumours
Neuronal imaging

Joober, Ridha

Rotation Program

Email Publications

ADHD
Schizophrenia

Animal models
Behaviour
Biomarkers
Diagnostics
Neuropsychology
Pharmacogenetics
Treatment

Juncker, David

Rotation Program

Email Website Publications

License

Neurodegeneration

Biomarkers
Diagnostics
Nanotechnologies

Kania, Artur

Rotation Program

Director, Neurobiology and Development research division , Director, Neural Circuit Development research unitEmail Website Publications

ALS
Basic Neuroscience
Neurodegeneration
Neurodevelopmental Disorders
Pain

Therapeutics
Axon
Motor function
Axon guidance
Behaviour
Chronic Pain
Ephrin-Eph Signalling
Genetics
Molecular Neuroscience
Netrin
Neural circuits
Neural development
Nociception
Spinal Cord
Chronic pain
Molecular neuroscience

Kennedy, Tim

Rotation Program

member, neurodeg. Disorder Res.Email Publications

Patents

License

Basic Neuroscience

Myelination
Neural development
Plasticity
Synapse

Khadra, Anmar

Rotation Program

Email Website Publications

Basic Neuroscience

Computational models
Neuronal rhythms

Khoutorsky, Arkady

Rotation Program

Email Website Publications

Basic Neuroscience

Autism
Mental disorders

Klein, Denise

Rotation Program

member, Cognitive NS groupEmail Publications

Cognitive Neuroscience

Diagnostics
Language
Neuroimaging

Kobayashi, Eliane

Rotation Program

member, Epilepsy Res. GroupEmail Website Publications

Epilepsy

Eeg
Genetics
Immunohistochemistry
Neuroimaging
Neurophysiology

Kokoeva, Maia

Rotation Program

Email Publications

Eating Disorders

Animal models
Electrophysiology
Genetics
Neuroendocrinology
Plasticity

Krishna, Suresh

Rotation Program

Dual Master's Program

Email Website Publications

Hearing
Vision

Attention
Computational models
Eye movement
Neurophysiology

Krishnaswamy, Arjun

Rotation Program

Email Website Publications

Basic Neuroscience
Cellular Neuroscience
Neurodevelopmental Disorders
Vision

Electrophysiology
Imaging
Neural circuits
Neural development
Optogenetics
Molecular Neuroscience
Retina

La Piana, Roberta

Rotation Program

Email Website Publications

Genomics
Leukodystrophies
Leukoencephalopathies
Multiple Sclerosis

Genetics
Neuroimaging
Diagnostics

Lamarche-Vane, Nathalie

Rotation Program

Rosalind and Morris Goodman Cancer Centre (GCC) - Interim ChairEmail Publications

Basic Neuroscience
Oncology

Animal models
In vitro assay
Neuroimaging
Neuronal navigation

Lavigne, Katie

Rotation Program

Email Website Publications

Cognitive Neuroscience
Mental Health

Computational models
Mental Health
Neuroimaging
Test development
e-health
Psychosis

Lehmann, Alexandre

Rotation Program

Email Website Publications

Behavioural Neuroscience
Cognitive Neuroscience
Hearing

Neuroimaging
Computational models
Plasticity
Sensory-motor processing

Levin, Mindy

Rotation Program

Tier 1 Canada Research Chair in Arm Motor Recovery and Rehabilitation (2005-2012).Email Website Publications

Basic Neuroscience
Physical Disabilities
Stroke

Diagnostics
Neurological lesion
Rehabilitation
Sensorimotor function
Spasticity

Leyton, Marco

Rotation Program

also in NeurologyEmail Publications

Addiction

Clinical investigation
Clinical research unit
Neuroimaging
Psychiatry

Li, Yue

Rotation Program

Email Website Publications

Basic Neuroscience
Bioinformatics
Genomics
Molecular psychiatry
Public Health
Statistical Genetics

Computational models
Genomics
Genetics
Single-cell technologies
Mining Electronic Health Records
Bayesian Fine-Mapping
Polygenic Risk Score Prediction

Lifshitz, Michael

Rotation Program

Email Publications

Ma, Weiya

Rotation Program

Email Publications

Pain

Animal models
Behaviour
Inflammation
Receptors

Masset, Paul

Rotation Program

Email Website Publications

Behavioural neuroscience
Cognitive Neuroscience
Machine Learning

Animal behaviour
Dopamine
Computational models
Decision making
Deep Learning

McBride, Heidi

Rotation Program

member, Rare Neurol Dis.,Email Website Publications

Basic Neuroscience
Neurodegeneration
Parkinson's Disease

Immunity
Mitochondria
Therapeutics

McKinney, Anne

Rotation Program

Email Website

Alzheimer's Disease
Ataxia
Autism
Basic Neuroscience
Epilepsy
Nanodelivery tools
Neurodevelopmental disorders

Animal models
Astrocyte
Microscopy
Neuroimaging
Neuroinflammation
Synapse
Therapeutics

Research Description:

Dr R Anne McKinney obtained her Ph.D, at the University of Ulster in 1992 after completing her BSc.(Hons)undergraduate degree in Biomedical Sciences at the University of Ulster, Northern Ireland. She then spent the next 5 years in the Department of Neurophysiology at the Brain Research Institute, University of Zurich as a postdoctoral fellow under the supervision of Profs S.M. Thompson and B.H Gähwiler. In 1998 she obtained her own group at the Brain Research Institute University of Zurich. Dr McKinney has recently joined the Department of Pharmacology and Therapeutics.
Dr. McKinneys principle research interest is the mechanisms involved in development and maintenance of excitatory synapses in the CNS, during physiological and pathological conditions, such as epilepsy and mental retardation. The synaptogenesis and maintenance of synaptic structures, key issues in neuroscience, are still poorly understood despite intensive research efforts. Her group’s studies are concentrated on the hippocampus a brain region thought to be involved in learning and memory. The McKinney lab is using a combination of techniques including, 4-dimensional confocal laser scanning microscopy, analysis of receptor subtype localization using serial electron microscopy, transgenic animals and advanced electrophysiological techniques to investigate the structure and function of dendritic spines and their synapses. These methods allows them assess the structural basis of synaptic function using multiple approaches.

McPherson, Peter

Rotation Program

member, neurodeg. Disorder Res., also in Neuro& neurosurgeryEmail Website Publications

Patents

License

Neurodegeneration

Cellular models
Endocytosis
Genetics
Membrane trafficking

Meaney, Michael

Rotation Program

Scientific Director at the Ludmer Centre for Neuroinformatics and Mental Health, Director, Program for the Study of Behaviour, Genes and Environment,Email Website Publications

Mental Health
Stress

Childhood abuse
Epigenetics
Genetics
Maternal care
Synapse

Meng, Xiangfei

Rotation Program

Email Website

Misic, Bratislav

Rotation Program

McConnell Brain Imaging CentreEmail Website Publications

Basic Neuroscience

Behaviour
Neuroimaging
Statistics

Mogil, Jeffrey

Rotation Program

Canada Research Chair in the Genetics of Pain (Tier I), E. P. Taylor Chair in Pain StudiesEmail Website Publications

Pain

Animal models
Behaviour
Genetics

Montembeault, Maxime

Rotation Program

Email Publications

Cognitive Neuroscience
Dementia
Neuropsychology

Language
Social communication
Diagnostics
Neuroimaging

Multhaup, Gerhard

Rotation Program

Email Website Publications

License

Alzheimer's Disease
Neurodegeneration

Amyloid
Biomarkers
Diagnostics
Prevention
Therapeutic targets
Cellular models

Munter, Lisa

Rotation Program

Email Publications

Alzheimer's Disease
Basic Neuroscience

Cholesterol
Therapeutic targets
Regulated intramembrane proteolysis

Murai, Keith

Rotation Program

Centre for Research in NeuroscienceEmail Website Publications

Basic Neuroscience
Mental Disorder

Immune-neural interaction
Ionic balance
Postsynaptic physiology
Synapse

Nagy, Corina

Rotation Program

Email Publications

Depression
Molecular psychiatry

Epigenetics
Extracellular vesicles
Genetics
Single-cell technologies

Nalbantoglu, Josephine

Rotation Program

member, NeuroImm. Res. GroupEmail Publications

Alzheimer's Disease
Oncology

Amyloid
Animal models
Genetics
Therapeutics

Narayanan, Sridar

Rotation Program

Email Website Publications

Multiple Sclerosis
Parkinson's Disease

Biomarkers
Clinical trials
Disease progression
Neuroimaging

Ohyama, Tomoko

Rotation Program

Email Website Publications

Basic Neuroscience

Neural circuits

Orlowski, John

Rotation Program

Email Website Publications

Patents

Basic Neuroscience
Intellectual Disability
Neurodevelopmental disorders

Imaging
Brain development
Neural ph homeostasis
Protein trafficking

Orri, Massimiliano

Rotation Program

Email Website Publications

Mental Health
Mood Disorder
Suicide

Epidemiology
Genetics
Psychiatry
Behaviour

Pack, Christopher

Rotation Program

group leader, Neural Circuits Res.Email Website Publications

Vision

Animal models
Modeling
Neurophysiology

Palaniyappan, Lena

Rotation Program

Email Website Publications

Cognitive Neuroscience
Mental Health
Neurodevelopmental Disorders
Schizophrenia

Youth
Childhood
Psychosis
Biomarkers
Psychiatry

Palmer, Caroline

Rotation Program

Canada Research Chair in cognitave Neuropsychology of Performance, Sequence Production Lab.Email Website Publications

Cognitive Neuroscience

Memory
Motor function
Music

Pell, Marc

Rotation Program

Associate Dean and Director, SCSDEmail Website Publications

Cognitive Neuroscience
Parkinson's Disease
Stroke

Behaviour
Emotions
Language
Neuropsychology

Pelufo Silveira, Patricia

Rotation Program

Email Publications

Basic Neuroscience
Behavioural neuroscience
Stress

Behaviour
Dopamine
Food intake

Peterson, Alan

Rotation Program

Dept. Of Oncology - MUHCEmail Publications

Patents

Multiple Sclerosis

Axon
Cytoskeleton
Immune-neural interaction
Myelination

Petrecca, Kevin

Rotation Program

neurosurgeon, group leader of Brain TumorEmail Website

Patents

Oncology

Brain tumours
Glial cells
Neurosurgery
Therapeutics

Petrides, Michael

Rotation Program

member Cognitive NS groupEmail Publications

Cognitive Neuroscience

Memory

Peyrache, Adrien

Rotation Program

Email Website Publications

Sleep

Animal models
Behaviour
Electrophysiology
Optogenetics

Poirier, Judes

Rotation Program

Director, Molecular Neurobiology Unit,Email Website Publications

Patents

Alzheimer's Disease

Genetics
Pharmacogenetics
Risk factor
Treatment

Poulin, Jean-Francois

Rotation Program

Email Website Publications

Basic Neuroscience
Behavioural neuroscience
Neurodevelopmental disorders
Parkinson's Disease

Neural development
Neuronal circuits
Dopamine
Animal models

Prager-Khoutorsky, Masha

Rotation Program

Email Website Publications

Basic Neuroscience

Animal models
Behaviour
Electrophysiology

Reynaud, Alexandre

Rotation Program

Email Website Publications

Cognitive Neuroscience
Vision

Binocular vision
Amblyopia
Neuroimaging
Psychophysics
Therapeutics

Ribeiro-da-Silva, Alfredo

Rotation Program

Email Website Publications

Pain

Animal models
Arthritis
Neuropathy
Therapeutics

Ristic, Jelena

Rotation Program

Lab for attention and social cognitionEmail Website Publications

Cognitive Neuroscience

Attention
Neuroimaging

Roig, Marc

Rotation Program

Email Website Publications

Basic Neuroscience

Memory consolidation
Motor learning
Motor memory

Rosa Neto, Pedro

Rotation Program

Director of Translational Neuroimaging LaboratoryEmail Publications

Alzheimer's Disease
Dementia
Neurodegeneration

Animal models
Biomarkers
Diagnostics
Neuroimaging

Roy, Mathieu

Rotation Program

Email Publications

Clinical epidemiology
Cognitive Neuroscience
Pain

Biomarkers of pain
Executive functions
Behaviour
Chronic pain
Neuroimaging
Psychology

Rudko, David

Rotation Program

Email Website Publications

Basic Neuroscience
Multiple Sclerosis
Neurodegeneration
Physics

Computational models
Microstructure
Neuroimaging
Animal models
MRI

Research in our lab is focused on the the application of novel MRI methodology in conjunction with biophysical modeling to augment the current understanding of brain anatomy and physiology. In neurological disease, the interplay between sub-voxel, cellular-level components such as microglia and axons executes a critical role in determining disease onset and progression. To investigate these features, our lab utilizes both small animal (7 T) and human MRI/MRS (3 T, 7 T) in conjunction with optical microscopy and advanced image processing methods. In particular, we develop MRI physics acquisition and post-processing techniques for mapping myelin density, axonal packing and axonal geometry.  Equally relevant, our lab also focuses on the advancement of physics, signal processing and hardware methodology for ultra-high field (UHF, > 3T) MRI. We develop computational and hardware/enginnering methods for (a) RF field homogenization (static and dynamic B1+ shimming methods) and (b) B0 shimming (B0 field mapping, gradient Z-shimming and multi-coil shim arrays).

Ruthazer, Edward

Rotation Program

member, neural Circuits Res.Email Website Publications

Autism
Basic Neuroscience
Schizophrenia
Vision

Animal models
Immune-neuro interactions
Neuroimaging
Plasticity
Electrophysiology
Neural circuits
Neuronal circuits

Sabatini, Paul

Rotation Program

Email Website Publications

Sakata, Jon

Rotation Program

Member CRBLMEmail Website

Autism
Cognitive Neuroscience

Animal models
Behaviour
Communication

Saragovi, Uri

Rotation Program

Email Website Publications

Patents

License

Basic Neuroscience
Neuroprotection
Vision

Neurotrophin
Rational drug design
Retinal ganglion cells
Therapeutics
Retinal degeneration

Research in my laboratory focuses in understanding macromolecular structure function relationships, particularly in receptor-ligand interactions. We apply this knowledge to translational research and to experimental therapeutics. We have contributed towards the development of protein mimicry technology (reviewed in Nature Biotechnology, 10: 773; Immunomethods 1: 3-12). Using molecular design, biochemistry, and molecular biology techniques large proteins may be dissected to their smallest functional units. These approaches can be adapted for rational drug design and the development of agonists and antagonists. We developed mimics of antibodies (Science, 253:792), cellular receptors (Proc. Natl. Acad. Sci. (USA), 89:5872-5876), and polypeptide growth factors (antagonists, e.g. J. Biol. Chem., 270:6564-6569; and agonists e.g. Jour. Neuroscience 16: 1308-1316; Chem & Biol. 12:1015-28). The small molecule mimetic ligands are better in vivo at imaging and localizing tumors compared to mAbs (Nature Biotechnology, 14:1120-1122). Structural studies of these small molecule artificial ligands demonstrated that they adopt the predicted configurations (J. Med. Chem. 43: 3541-3548, Jour Biol Chem. 273:23652-23658). Pharmacological studies demonstrated that these small molecule designed agents can be useful as drugs or drug leads. We have succeeded in using these agents in various in vivo models of neurodegeneration (cognitive impairment in ageing, glaucoma) (J. Neurosci, 24:8009-18; J. Neurobiol. 58:341-54) and of cancer (Cancer Res. 2001 61:694-9). In vivo experimental cancer therapeutic studies have shown that our approaches improve the therapeutic index of useful (yet toxic) drugs by many fold, and more importantly help to by pass drug resistance (Oncogene 23:3613-21). Small molecules can be used to identify the relevant sites on receptors that can induce a biological response (Trends in Pharmacological Sciences 21: 93-98. Molec. Pharmacol. 57:385-391. Expert Opinion in Therapeutic Patents 9: 737-751). Using the small molecule ligands we can carry out fine studies of receptor biology (Jour Biol Chem. 275: 9946-9956. Proc. Natl. Acad. Sci. (USA) 96:4067-4072. Jour Biol Chem. 273: 34933-34940. Jour. Neuroscience 17: 6031-6037; J. Biol. Chem 276:1023-1029) such as studies of cross-regulation by different receptor activation sites, and biophysical analyses of ligand-receptor interactions. Recently we extended the concept of ligand mimicry to develop functional ligands of non-protein targets such as gangliosides. This is the first demonstration of a designed, synthetic, functional, small molecule ligand selective for a carbohydrate moiety, and builds on the recent conceptual breakthrough that gangliosides can be true functional cell surface receptors.

Schweinhardt, Petra

Rotation Program

Alan Edwards Centre for Research on PainEmail Website

Pain

Dopamine
Memory
Neuroimaging
Neurotransmitters
Psychopharmacology

Shah, Jai

Rotation Program

Email Website Publications

Psychosis

Biomarkers
Neuroinflammation
Stress

Sharif Naeini, Reza

Rotation Program

Email Website Publications

Patents

Mechanotransduction
Pain

Ion channels
Neural circuits
Neuronal circuits
Therapeutic

We are interested in understanding the molecular bases of mechanotransduction, and the role of mechanosensory neurons in normal and pathological pain transmission. Mechanotransduction, the process through which cells convert a mechanical stimulus into an electrical signal, is of fundamental importance to physiological functions such as our senses of touch (including pain) and hearing, as well as our ability to regulate our hydromineral homeostasis (thirst), baroreflex function and myogenic tone (regulation of blood pressure). Mechanosensitive ion channels are membrane proteins responsible for most mechanotransduction processes, yet their molecular identity has not been fully resolved. Because these channels are involved in several pathologies of the nervous (chronic pain, deafness) and cardiovascular (hypertension) systems, the molecular identification of these channels, and understanding their activation properties may lead to the development of new therapeutic strategies in several clinical areas. The projects in the lab focus on two areas of research: (1) Identification of the molecular mechanisms underlying neuronal mechanotransduction. and (2) Identification of central (spinal cord) neuronal circuits engaged by mechanosensory afferents in control or during chronic pain conditions.

Sheldon, Signy

Rotation Program

Email Website

Shmuel, Amir

Rotation Program

Email Website Publications

Basic Neuroscience
Vision

Neuroimaging
Neurophysiology

Shoubridge, Eric

Rotation Program

Email Website Publications

Basic Neuroscience

Genetics
Mitochondria

Shultz, Thomas

Rotation Program

Associate Member of the School of Computer ScienceEmail Website Publications

Cognitive Neuroscience

Computational models
Development
Learning

Sjöström, Jesper

Rotation Program

Centre for Research in Neuroscience at the Research Institute MUHCEmail Website Publications

Cellular Neuroscience

Computational models
Electrophysiology
Memory
Microscopy
Neural circuits
Neuronal circuits
Neurotransmitters
Optogenetics

Small, Dana

Rotation Program

Email Publications

Sossin, Wayne

Rotation Program

member, neural Circuits Res.Email Website Publications

Autism
Basic Neuroscience
Behavioural Neuroscience
Neurodevelopmental Disorders

Memory
Synapse
Electrophysiology
Signaling pathways
Molecular Neuroscience

Srivastava, Lalit K.

Rotation Program

Email Publications

Schizophrenia

Animal models
Dopamine
Genetics
Neurodevelopment

Stellwagen, David

Rotation Program

Email Website Publications

Patents

Addiction
ALS
Autism
Huntington's disease
Neurodegeneration
Parkinson's Disease

Immune-neural interaction
TNF
Inflammation
Synapse

Stifani, Stefano

Rotation Program

member of Brain Tumor GroupEmail Website Publications

ALS
Basic Neuroscience
Oncology

Motor neurons
Neural circuits
Neuronal circuits
Brain tumours
Neural development

Storch, Florian

Rotation Program

Email Website Publications

Basic Neuroscience

Animal models
Circadian rhythms
Genetics

The role of the multi-oscillator circadian timing system in physiology and behavior: By employing genetic dissection strategies we want to i) explore the biological significance of peripheral clocks located outside the suprachiasmatic nucleus (SCN) and ii) test the hypothesis that the SCN is functionally compartmentalized. It is believed that circadian clocks in the central nervous system play important roles in the control of various brain functions including the regulation of the sleep-wake cycle, locomotion, body weight, reproduction, and reward processing. We will rigorously examine these links by genetically manipulating clock function in selected brain structures as well as tissues and organs that are targets of neuroendocrine regulation such as the pituitary, gonads and adrenal glands. This research will likely yield fundamental insights in how our internal 24-hour timers effects the nervous system and may thus pave the way for new concepts to tackle mental disorders and other brain dysfunctions

Stratton, Jo Anne

Rotation Program

Email Publications

Multiple Sclerosis

Animal models
Disease progression
Immune-neural interaction

Stroh, Thomas

Rotation Program

supervises the MNI Microscopy Unit. This comprises common microscopic equipment of the MNI such as confocal microscopes, laser micromanipulation, and stereologic equipment.Email Website Publications

Basic Neuroscience

GPCR
Microscopy
Neuropharmacology
Somatostatin receptors

Takahashi, Hideto

Rotation Program

Director, Synapse Development and Plasticity research unitEmail Website Publications

Autism
Cognitive Neuroscience
Schizophrenia

Genetics
Learning
Memory
Plasticity
Synapse
Therapeutics

Thebault, Simon

Rotation Program

Email Publications

Multiple Sclerosis
Neuroimmunology

Biomarkers
Inflammation

Trenholm, Stuart

Rotation Program

Email Website Publications

Tritsch, Nicolas

Rotation Program

Email Website Publications

Basic Neuroscience
Cellular Neuroscience
Cognitive Neuroscience
Mood Disorder

Synapse
Neural circuits
Plasticity
Psychiatry

Turecki, Gustavo

Rotation Program

Director, McGill Group for Suicide Studies, Head, Depressive Disorders Program, Douglas InstituteEmail Website Publications

Depression
Suicide

Biomarkers
Environment
Epigenetics
Prevention
Treatment

Van Meyel, Donald

Rotation Program

Centre for Research in NeuroscienceEmail Website Publications

Basic Neuroscience

Animal models
Axon
Dendrite
Genetics
Hedgehog
Immune-neural interaction
Neuroimaging

Van Raamsdonk, Jeremy

Rotation Program

Email Website Publications

Aging
Genetics
Huntington's Disease
Neuroprotection
Parkinson's Disease

Oxidative Stress
C. elegans
Mitochondria
Neurodegenerative Disease
Animal models

Velly, Ana

Rotation Program

Email Website Publications

Clinical epidemiology

Adverse events related to the management of chronic pain
Biomarkers of pain
Epidemiology of acute and chronic pain
Management of Chronic Pain
Transition from acute to chronic pain

Villeneuve, Sylvia

Rotation Program

Email Website Publications

Alzheimer's Disease

Amyloid
Biomarkers
Neuroimaging
Neuropsychology
Risk factor
Tau
Therapeutics

Vollrath, Melissa

Rotation Program

Associate Prof. Exp. MedEmail Publications

Basic Neuroscience

Animal models
Ion channels
Sensory neurobiology

Walker, Claire-Dominique

Rotation Program

Director, Neuroscience Research Division, Douglas InstituteEmail Publications

Basic Neuroscience
Stress

Endocannabinoids
Environment
Maternal behaviour
Plasticity
Development
Food intake

Watt, Alanna

Rotation Program

Email Website Publications

Basic Neuroscience
Neurodegeneration

Aging
Animal models
Ataxia
Electrophysiology
Imaging
Motor behaviour
Neural circuits

Williams, Sylvain

Rotation Program

Electrophysiology, theta and gamma rhythms, hippocampus, optogenetics.Email Website Publications

Alzheimer's Disease
Cognitive Neuroscience
Schizophrenia

In vitro assay
Learning
Memory
Neural circuits
Neuronal circuits
Electrophysiology

Wintermark, Pia

Rotation Program

Pediatrician and Neonatologist, MCH & RVH Director, NeobrainlabEmail Website Website Publications

Basic Neuroscience
Neuroinflammation
Stroke
Vision

Animal models
Asphyxia
Brain blood flow
Diagnostics
Eeg
Neonatal
Neuroimaging
Therapeutics
EEG

Wolfson, Christina

Rotation Program

co-lead on a national study on aging, The Canadian Longitudinal Study on Aging, - appointed McGill’s new Deputy Research Integrity Officer, commencing on January 1, 2016. Effective June 1, 2016, Dr. Wolfson will become McGill’s Research Integrity OffiEmail Publications

Multiple Sclerosis
Parkinson's Disease

Risk factors
Disease course
Therapeutic target

Wong, Tak Pan

Rotation Program

Dual Master's Program

Woolley, Sarah

Rotation Program

Email Website

Cognitive Neuroscience

Animal models
Behaviour
Communication
Computational models
Electrophysiology
Learning

Zandee, Stephanie

Rotation Program

Email Publications

Zatorre, Robert

Rotation Program

member, Cognitive NS groupEmail Publications

Cognitive Neuroscience
Hearing

Language
Music
Neuroimaging

Zeighami, Yashar

Rotation Program

Dual Master's Program

Email Website Publications

Aging
Basic Neuroscience
Cognitive Neuroscience
Dementia
Neurodegeneration

Brain and Cognitive Changes
Neuroinformatics
Computational models
Biomarkers
Neuroimaging

Zhang, Ji

Rotation Program

Email Website

Pain

Animal models
Behaviour
Immune-neural interaction
Therapeutic

Zhou, Yang

Rotation Program

Dual Master's Program

Email Publications

Basic Neuroscience
Neurodevelopmental disorders
Neurodevelopmental Disorders

Therapeutics
Animal models
Molecular Neuroscience

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