François Dubeau, MD



Dr. Dubeau is the head of the EEG department at the MNI. He is a neurologist specializing in epilepsy, and uses depth electrodes to determine epileptogenic foci that cannot be found by surface electroencephalography. Dr. Dubeau has been very active in collaborations with our group, and instrumental in providing patients for our studies.





Montreal Neurological Institute

3801 University Street

EEG department

H3A 2B4 Montreal


Peer Reviewed Publications since 2000:


Gotman J, Grova C, Bagshaw A, Kobayashi E, Aghakhani Y, Dubeau F. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15236-40. Epub 2005 Oct 10.

Kobayashi E, Bagshaw AP, Grova C, Dubeau F, Gotman J.  Negative BOLD responses to epileptic spikes. Hum Brain Mapp. 2005 Sep 22; [Epub ahead of print]

Al-Asmi A, Jansen AC, Badhwar A, Dubeau F, Tampieri D, Shustik C, Mercho S, Savard G, Dobson-Stone C, Monaco AP, Andermann F, Andermann E.  Familial temporal lobe epilepsy as a presenting feature of choreoacanthocytosis. Epilepsia. 2005 Aug;46(8):1256-63.

Palmini A, Halasz P, Scheffer IE, Takahashi Y, Jimenez AP, Dubeau F, Andermann F, Paglioli-Neto E, da Costa JC, Rosenow F, Fritsch B.  Reflex seizures in patients with malformations of cortical development and refractory epilepsy. Epilepsia. 2005 Aug;46(8):1224-34.

Stefanovic B, Warnking JM, Kobayashi E, Bagshaw AP, Hawco C, Dubeau F, Gotman J, Pike GB.  Hemodynamic and metabolic responses to activation, deactivation and epileptic discharges. Neuroimage. 2005 Oct 15;28(1):205-15. Epub 2005 Jul 5.

Yankovsky AE, Veilleux M, Dubeau F, Andermann F.  Post-ictal rage and aggression: a video-EEG study. Epileptic Disord. 2005 Jun;7(2):143-7.

Dobson-Stone C, Velayos-Baeza A, Jansen A, Andermann F, Dubeau F, Robert F, Summers A, Lang AE, Chouinard S, Danek A, Andermann E, Monaco AP. Identification of a VPS13A founder mutation in French Canadian families with chorea-acanthocytosis.Neurogenetics. 2005 Sep;6(3):151-8. Epub 2005 Sep 28.
Siegel AM, Cascino GD, Elger CE, Devinsky O, Laff R, Najjar S, Sperling MR, LoRusso G, Cossu M, Urbach H, Aronica E, Meyer FB, Scheithauer BW, Dubeau F, Andermann F.  Adult-onset epilepsy in focal cortical dysplasia of Taylor type. Neurology. 2005 May 24;64(10):1771-4.

Kobayashi E, Bagshaw AP, Jansen A, Andermann F, Andermann E, Gotman J, Dubeau F.  Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses. Neurology. 2005 Apr 12;64(7):1263-6.

Navarro V, Martinerie J, Le Van Quyen M, Baulac M, Dubeau F, Gotman J. Seizure anticipation: do mathematical measures correlate with video-EEG evaluation? Epilepsia. 2005 Mar;46(3):385-96.

Bagshaw AP, Hawco C, Benar CG, Kobayashi E, Aghakhani Y, Dubeau F, Pike GB, Gotman J.  Analysis of the EEG-fMRI response to prolonged bursts of interictal epileptiform activity. Neuroimage. 2005 Feb 15;24(4):1099-112. Epub 2004 Dec 1.

Sheen VL, Jansen A, Chen MH, Parrini E, Morgan T, Ravenscroft R, Ganesh V, Underwood T, Wiley J, Leventer R, Vaid RR, Ruiz DE, Hutchins GM, Menasha J, Willner J, Geng Y, Gripp KW, Nicholson L, Berry-Kravis E, Bodell A, Apse K, Hill RS, Dubeau F, Andermann F, Barkovich J, Andermann E, Shugart YY, Thomas P, Viri M, Veggiotti P, Robertson S, Guerrini R, Walsh CA.  
Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome. Neurology. 2005 Jan 25;64(2):254-62.

Aghakhani Y, Kinay D, Gotman J, Soualmi L, Andermann F, Olivier A, Dubeau F.  The role of periventricular nodular heterotopia in epileptogenesis. Brain. 2005 Mar;128(Pt 3):641-51. Epub 2005 Jan 19.

Gotman J, Benar CG, Dubeau F.  Combining EEG and FMRI in epilepsy: methodological challenges and clinical results.
J Clin Neurophysiol. 2004 Jul-Aug;21(4):229-40.

Berkovic SF, Serratosa JM, Phillips HA, Xiong L, Andermann E, Diaz-Otero F, Gomez-Garre P, Martin M, Fernandez-Bullido Y, Andermann F, Lopes-Cendes I, Dubeau F, Desbiens R, Scheffer IE, Wallace RH, Mulley JC, Pandolfo M.  Familial partial epilepsy with variable foci: clinical features and linkage to chromosome 22q12. Epilepsia. 2004 Sep;45(9):1054-60.

Kinay D, Dubeau F, Andermann F, Olivier A.  Palliative temporal resection for the treatment of intractable bioccipital epilepsy. Epileptic Disord. 2004 Jun;6(2):97-105.

Mintzer S, Cendes F, Soss J, Andermann F, Engel J Jr, Dubeau F, Olivier A, Fried I.  Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset. Epilepsia. 2004 Jul;45(7):792-802.

Aghakhani Y, Rosati A, Olivier A, Gotman J, Andermann F, Dubeau F.  The predictive localizing value of tonic limb posturing in supplementary sensorimotor seizures.
Neurology. 2004 Jun 22;62(12):2256-61.

D'Agostino MD, Bastos A, Piras C, Bernasconi A, Grisar T, Tsur VG, Snipes J, Juhasz C, Chugani H, Guerrini R, Cross H, Andermann E, Dubeau F, Montes J, Olivier A, Andermann F.  Posterior quadrantic dysplasia or hemi-hemimegalencephaly: a characteristic brain malformation. Neurology. 2004 Jun 22;62(12):2214-20.

Bagshaw AP, Aghakhani Y, Benar CG, Kobayashi E, Hawco C, Dubeau F, Pike GB, Gotman J.  EEG-fMRI of focal epileptic spikes: analysis with multiple haemodynamic functions and comparison with gadolinium-enhanced MR angiograms. Hum Brain Mapp. 2004 Jul;22(3):179-92.

Aghakhani Y, Bagshaw AP, Benar CG, Hawco C, Andermann F, Dubeau F, Gotman J.  fMRI activation during spike and wave discharges in idiopathic generalized epilepsy. Brain. 2004 May;127(Pt 5):1127-44. Epub 2004 Mar 19.

Aghakhani Y, Rosati A, Dubeau F, Olivier A, Andermann F.  Patients with temporoparietal ictal symptoms and inferomesial EEG do not benefit from anterior temporal resection. Epilepsia. 2004 Mar;45(3):230-6.

Savard G, Bhanji NH, Dubeau F, Andermann F, Sadikot A.  Psychiatric aspects of patients with hypothalamic hamartoma and epilepsy. Epileptic Disord. 2003 Dec;5(4):229-34.

Kang JK, Benar C, Al-Asmi A, Khani YA, Pike GB, Dubeau F, Gotman J.  Using patient-specific hemodynamic response functions in combined EEG-fMRI studies in epilepsy. Neuroimage. 2003 Oct;20(2):1162-70.

Al-Asmi A, Benar CG, Gross DW, Khani YA, Andermann F, Pike B, Dubeau F, Gotman J.  fMRI activation in continuous and spike-triggered EEG-fMRI studies of epileptic spikes. Epilepsia. 2003 Oct;44(10):1328-39.

Kobayashi E, D'Agostino MD, Lopes-Cendes I, Andermann E, Dubeau F, Guerreiro CA, Schenka AA, Queiroz LS, Olivier A, Cendes F, Andermann F.  Outcome of surgical treatment in familial mesial temporal lobe epilepsy. Epilepsia. 2003 Aug;44(8):1080-4.

Guerrini R, Moro F, Andermann E, Hughes E, D'Agostino D, Carrozzo R, Bernasconi A, Flinter F, Parmeggiani L, Volzone A, Parrini E, Mei D, Jarosz JM, Morris RG, Pratt P, Tortorella G, Dubeau F, Andermann F, Dobyns WB, Das S.  Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations. Ann Neurol. 2003 Jul;54(1):30-7.

Rosati A, Aghakhani Y, Bernasconi A, Olivier A, Andermann F, Gotman J, Dubeau F.  Intractable temporal lobe epilepsy with rare spikes is less severe than with frequent spikes. Neurology. 2003 Apr 22;60(8):1290-5.

Benar C, Aghakhani Y, Wang Y, Izenberg A, Al-Asmi A, Dubeau F, Gotman J.  Quality of EEG in simultaneous EEG-fMRI for epilepsy. Clin Neurophysiol.
2003 Mar;114(3):569-80.

Natsume J, Kumakura Y, Bernasconi N, Soucy JP, Nakai A, Rosa P, Fedi M, Dubeau F, Andermann F, Lisbona R, Bernasconi A, Diksic M.  
Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy. Neurology. 2003 Mar 11;60(5):756-61.
Lee S, Sziklas V, Andermann F, Farnham S, Risse G, Gustafson M, Gates J, Penovich P, Al-Asmi A, Dubeau F, Jones-Gotman M.  The effects of adjunctive topiramate on cognitive function in patients with epilepsy. Epilepsia. 2003 Mar;44(3):339-47.

Fedi M, Reutens DC, Andermann F, Okazawa H, Boling W, White C, Dubeau F, Nakai A, Gross DW, Andermann E, Diksic M.  alpha-[11C]-Methyl-L-tryptophan PET identifies the epileptogenic tuber and correlates with interictal spike frequency. Epilepsy Res. 2003 Jan;52(3):203-13.

Abosch A, Bernasconi N, Boling W, Jones-Gotman M, Poulin N, Dubeau F, Andermann F, Olivier A. Factors predictive of suboptimal seizure control following selective amygdalohippocampectomy. J Neurosurg.
2002 Nov;97(5):1142-51.

Benar CG, Gross DW, Wang Y, Petre V, Pike B, Dubeau F, Gotman J.  The BOLD response to interictal epileptiform discharges. Neuroimage. 2002 Nov;17(3):1182-92.

D'Agostino MD, Bernasconi A, Das S, Bastos A, Valerio RM, Palmini A, Costa da Costa J, Scheffer IE, Berkovic S, Guerrini R, Dravet C, Ono J, Gigli G, Federico A, Booth F, Bernardi B, Volpi L, Tassinari CA, Guggenheim MA, Ledbetter DH, Gleeson JG, Lopes-Cendes I, Vossler DG, Malaspina E, Franzoni E, Sartori RJ, Mitchell MH, Mercho S, Dubeau F, Andermann F, Dobyns WB, Andermann E. Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females. Brain. 2002 Nov;125(Pt 11):2507-22.

Boling W, Andermann F, Reutens D, Dubeau F, Caporicci L, Olivier A.  Surgery for temporal lobe epilepsy in older patients.
J Neurosurg. 2001 Aug;95(2):242-8.

Fedi M, Reutens D, Okazawa H, Andermann F, Boling W, Dubeau F, White C, Nakai A, Gross DW, Andermann E, Diksic M.  Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin. Neurology. 2001 Nov 13;57(9):1629-36.

Bernasconi A, Martinez V, Rosa-Neto P, D'Agostino D, Bernasconi N, Berkovic S, MacKay M, Harvey AS, Palmini A, da Costa JC, Paglioli E, Kim HI, Connolly M, Olivier A, Dubeau F, Andermann E, Guerrini R, Whisler W, de Toledo-Morrell L, Morrell F, Andermann F.  Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results. Epilepsia. 2001 Sep;42(9):1124-9.

Sheen VL, Dixon PH, Fox JW, Hong SE, Kinton L, Sisodiya SM, Duncan JS, Dubeau F, Scheffer IE, Schachter SC, Wilner A, Henchy R, Crino P, Kamuro K, DiMario F, Berg M, Kuzniecky R, Cole AJ, Bromfield E, Biber M, Schomer D, Wheless J, Silver K, Mochida GH, Berkovic SF, Andermann F, Andermann E, Dobyns WB, Wood NW, Walsh CA. Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females. Hum Mol Genet. 2001 Aug 15;10(17):1775-83.

Duncan S, Mercho S, Lopes-Cendes I, Seni MH, Benjamin A, Dubeau F, Andermann F, Andermann E.  Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality. Epilepsia. 2001 Jun;42(6):750-3.

Bernasconi A, Antel SB, Collins DL, Bernasconi N, Olivier A, Dubeau F, Pike GB, Andermann F, Arnold DL.  Texture analysis and morphological processing of magnetic resonance imaging assist detection of focal cortical dysplasia in extra-temporal partial epilepsy. Ann Neurol. 2001 Jun;49(6):770-5.

Bernasconi N, Bernasconi A, Caramanos Z, Dubeau F, Richardson J, Andermann F, Arnold DL.  Entorhinal cortex atrophy in epilepsy patients exhibiting normal hippocampal volumes. Neurology. 2001 May 22;56(10):1335-9.

Fedi M, Reutens D, Dubeau F, Andermann E, D'Agostino D, Andermann F. Free Full Text Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy. Arch Neurol. 2001 May;58(5):781-6.

Serles W, Li LM, Antel SB, Cendes F, Gotman J, Olivier A, Andermann F, Dubeau F, Arnold DL.  Time course of postoperative recovery of N-acetyl-aspartate in temporal lobe epilepsy. Epilepsia. 2001 Feb;42(2):190-7.

Bernasconi A, Andermann F, Bernasconi N, Reutens DC, Dubeau F.
 Lateralizing value of peri-ictal headache: A study of 100 patients with partial epilepsy.
Neurology. 2001 Jan 9;56(1):130-2.

Bernasconi A, Bernasconi N, Caramanos Z, Reutens DC, Andermann F, Dubeau F, Tampieri D, Pike BG, Arnold DL.  T2 relaxometry can lateralize mesial temporal lobe epilepsy in patients with normal MRI. Neuroimage. 2000 Dec;12(6):739-46.

Li LM, Narayanan S, Pike GB, Andermann F, Dubeau F, Arnold DL. Magnetization transfer ratio is unable to lateralize epileptic foci in patients with temporal lobe epilepsy. AJNR Am J Neuroradiol. 2000 Nov-Dec;21(10):1853-6.

Trinka E, Dubeau F, Andermann F, Bastos A, Hui A, Li LM, Kohler S, Olivier A. Clinical findings, imaging characteristics and outcome in catastrophic post-encephalitic epilepsy. Epileptic Disord. 2000 Sep;2(3):153-62.

Gross DW, Dubeau F, Quesney LF, Gotman J.  EEG telemetry with closely spaced electrodes in frontal lobe epilepsy.
J Clin Neurophysiol. 2000 Jul;17(4):414-8.

D'Agostino MD, Andermann F, Dubeau F, Fedi M, Bastos A.  Exceptionally long absence status: multifactorial etiology, drug interactions and complications.Epileptic Disord. 1999 Dec;1(4):229-32.

Bernasconi N, Bernasconi A, Caramanos Z, Andermann F, Dubeau F, Arnold DL.  Morphometric MRI analysis of the parahippocampal region in temporal lobe Epilepsy. Ann N Y Acad Sci. 2000 Jun;911:495-500.

Li LM, Caramanos Z, Cendes F, Andermann F, Antel SB, Dubeau F, Arnold DL.  Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data. Epilepsia. 2000 Jul;41(7):832-42.

Li LM, Dubeau F, Andermann F, Arnold DL.  Proton magnetic resonance spectroscopic imaging studies in patients with newly diagnosed partial epilepsy. Epilepsia. 2000 Jul;41(7):825-31.

Trinka E, Dubeau F, Andermann F, Hui A, Bastos A, Li LM, Kohler S, Olivier A.  Successful epilepsy surgery in catastrophic postencephalitic epilepsy. Neurology. 2000 Jun 13;54(11):2170-3.

Li LM, Cendes F, Andermann F, Dubeau F, Arnold DL.  Spatial extent of neuronal metabolic dysfunction measured by proton MR spectroscopic imaging in patients with localization-epilepsy. Epilepsia. 2000 Jun;41(6):666-74.

Dubeau F, McLachlan RS.  Invasive electrographic recording techniques in temporal lobe epilepsy. Can J Neurol Sci. 2000 May;27 Suppl 1:S29-34; discussion S50-2. Review.

Cendes F, Li LM, Watson C, Andermann F, Dubeau F, Arnold DL Is ictal recording mandatory in temporal lobe epilepsy? Not when the interictal electroencephalogram and hippocampal atrophy coincide. Arch Neurol. 2000 Apr;57(4):497-500.

Miller SP, Li LM, Cendes F, Tasch E, Andermann F, Dubeau F, Arnold DL.  Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy. Neurology. 2000 Apr 11;54(7):1465-70.

Li LM, Cendes F, Antel SB, Andermann F, Serles W, Dubeau F, Olivier A, Arnold DL.  Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. Ann Neurol. 2000 Feb;47(2):195-200.

Dubeau F, De Stefano N, Zifkin BG, Arnold DL, Shoubridge EA.  Oxidative phosphorylation defect in the brains of carriers of the tRNAleu(UUR) A3243G mutation in a MELAS pedigree. Ann Neurol. 2000 Feb;47(2):179-85.